利用鈀金屬催化進行碳氫鍵活化合成芴酮

Palladium-catalyzed C-H activation for the synthesis Fluorenone

黃俊銘(Jun-Min Huang)

指導教授 ： 謝仁傑

淡江大學/理學院/化學學系碩士班/碩士(2013年)

https://doi.org/10.6846/TKU.2013.00526

摘要

(1)利用Suzuki-Miyaura coupling reaction方式合成聯苯腈起始物(2)利用[Pd]/[Ag]/TFA系統催化聯苯腈類起始物進行碳-氫鍵活化合成芴酮。利用實驗室所得到最佳化反應條件:(1) 0.5 mmol(1當量) 聯苯睛，10 mol% Pd(MeCN)2Cl2、20 mol % AgTFA、1.1當量 H2O、1.5 mL TFA、0.75 mL DMA。

關鍵字

聯苯腈 ； 碳氫鍵活化 ； 芴酮

並列摘要

The biphenyl derivatives were synthesized by Suzuki- Miyaura coupling reaction to obtain the starting materials. A novel procedure employed [Pd]/[Ag]/TFA system catalyzed cascade reactions of nitrile directed remote C-H bond activation that afforded variously polysubstituted fluorenones in moderate to good yields with tolerance of a wide variety of substrates.

並列關鍵字

Suzuki-Miyaura coupling reaction ； C-H activation ； Fluorenone

參考文獻

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