First part: Fluorescent bioprobe is one of the form to trace that the drug react in the body. We successfully synthesize the drug bearing with fluorescent bioprobe, for example, oxaliplatin, aspirin. In the further, we hope to find the new biochemical reaction or the new treatment for disease in the body. Second part: Sofusbuvir is the drug on the market, which is applying patent copyright. In order to avoid the patent copyright,we try to improve the process and find the new crystalline form. If the project is successful , we have the legal to manufacture and sell.