明膠基底人工血管之初探

A Preliminary Study of Gelatin-Based Blood Vessels

陳柏宏(Bo-Hong Chen)

指導教授 ： 楊龍杰

淡江大學/工學院/機械與機電工程學系碩士班/碩士(2011年)

https://doi.org/10.6846/TKU.2011.01052

摘要

本文主要是利用重鉻酸鉀明膠溶液「鹽析」產生出之碎形微圖案，並利用其特性用以製作人工血管。經本實驗之參數配置測試，碎形圖案之尺寸會因明膠、重鉻酸鉀重量百分比與旋塗厚度參數而有所改變，可測得之碎形尺寸範圍約可達水力直徑0.1-23μm。此微圖案之樣貌、結構，與肝門靜脈相似，而尺寸目前洽可符合中末段微靜脈部分，若能將之做成人工血管，針對遭阻塞之肝門靜脈，或許能達成降壓甚至置換之功能。本文將利用聚二甲基矽氧烷多項與生物相容之特性來製作血管流道，首先藉由SU-8翻模將碎形微圖案製成管道，接著利用氧氣電漿將之與玻璃基材接合，成功製出類血管之流道。

關鍵字

明膠 ； 碎形 ； 聚二甲基矽氧烷 ； 人工血管

並列摘要

In this study, the author proposed developing a novel gelatin micromachining technique which focuses on solving the first issue for gelatin micro patterns applied to stem cell culture with fractal dendrite configuration. Such a chaotic tree-like fractal patterns have been verified through precipitating among the gelatin film matrix which is spun coating on a glass substrate at the room temperature. The weight percentage of the gelatin matrix is over-saturated. As the temperature decrease, the gelatine will crystallize and to form a natural fractal pattern. When the parameters change, the equivalent diameter of the fractal patterns ranges from 0.1 to 23 micro-meter. Then the author used the biocompatibility properties of PDMS making blood vessel like channels by turnover formwork or the soft lithography. The oxygen plasma treatment on the PDMS before bonding to the glass substrate is done accordingly.

並列關鍵字

Gelatin ； Fractal ； PDMS ； Blood Vessels

參考文獻

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