早產及呼吸窘迫是否與氣喘及下呼吸道感染住院有關?

Are Preterm and Respiratory Distress associated with Asthma and Hospitalization due to Lower Respiratory Tract Infection?

余偉豪(Wa-Hau Yu)

指導教授 ： 葉志嶸

中山醫學大學/健康管理學院/公共衛生學系碩士班/碩士(2012年)

https://doi.org/10.6834/CSMU.2012.00011

摘要

研究目的：探討早產及呼吸窘迫與氣喘及下呼吸道感染住院之相關性
，以及出生體重與氣喘及下呼吸道感染住院之相關性。

材料方法：全民健保資料庫2000年20萬人抽樣歸人檔 ，以世代追蹤研究設計，分析1996年至2000年出生世代，早產、呼吸窘迫、及低出生體重，對後續呼吸道疾病發生之風險。

研究結果：早產世代氣喘發生風險之HR為1.32倍；下呼吸道感染住院之一次以上(每年)、兩次以上(每年)、三次以上(每年)發生風險之HR分別為1.26倍、1.59倍、3.31倍。呼吸窘迫出生世代氣喘發生風險之HR為1.04倍；下呼吸道感染住院之一次以上(每年)、兩次以上(每年)、三次以上(每年)發生風險之HR分別為1.43倍、1.80倍、1.04倍。出生體重<1,500克、1,500-2,500克之出生世代，相較於體重>2,500克之世代，其氣喘發生風險之HR為1.59倍及1.27倍；下呼吸道感染住院之一次以上(每年)、兩次以上(每年)、三次以上(每年)發生風險之HR分別為1.68倍與2.96倍、5.64倍與1.16倍、以及1.26倍與2.93倍。

結論：早產會增加嬰幼兒氣喘發生及下呼吸道感染住院之風險。呼吸窘迫於考量早產因素後，與氣喘發生無顯著相關，但仍增加下呼吸道感染住院之風險；出生體重越輕，嬰幼兒氣喘發生及下呼吸道感染住院風險越高。

關鍵字

早產 ； 呼吸窘迫 ； 氣喘 ； 下呼吸道感染住院 ； 全民健康保險

並列摘要

Purposes：Investigating the associated of preterm and respiratory distress with asthma and hospitalization due to lower respiratory tract infection, as well as exploring the associated of birth weight with asthma and hospitalization due to lower respiratory tract infection.

Materials and Methods：The database is composed of 200,000 subjects whom were randomly selected from National health Insurance Database. The study is a cohort study design to analysis the risk of preterm、respiratory distress and birth weight for respiratory tract disease in the cohort who birth since 1996 to 2000 .

Results：Preterm cohort in the cox regression show the hazard ration for asthma【HR=1.32】and once、twice and three times hospitalization due to lower respiratory distress infection every year respectively【HR=1.26】、【HR=1.59】、【HR=3.31】. Respiratory distress cohort in the cox- regression show the hazard ration for asthma 【HR=1.04】and once 、twice and three times hospitalization due to lower respiratory distress infection every year respectively【HR=1.43】、【HR=1.80】、【HR=1.04】. Birth weight<1500g、1500-2500g compare to birth weight>2500g cohort in the cox regression show the hazard ratio for asthma respectively 【HR=1.59】、【HR=1.27】, and once 、twice and three times hospitalization due to lower respiratory distress infection every year respectively【HR=1.68】【HR=2.96】、【HR=5.64】【HR=1.16】and【HR=1.26】【HR=2.93】.

Conclusion：Preterm will increased the risk of asthma and hospitalization due to lower respiratory tract infection . After adjusted for preterm, the risk of asthma for respiratory distress cohort is not associate, but it still increased the risk of hospitalization due to lower respiratory tract infection. The more lighter birth weight, the higher the risk of asthma and hospitalization due to lower respiratory tract infection.

並列關鍵字

Preterm ； Respiratory Distress ； Asthma ； Hospitalization due to Lower Respiratory Tract Infection ； National Health Insurance Database

參考文獻

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