熱可塑聚氨酯與氫氧基磷灰石複合材料做為人工髖關節的生物相容性與機械性質分析

Analysis the Biocompatibilities and Mechanical Properites of TPU/HA Composited Artificial Hip Joint

雷震邦(Jeen-Bon Lei)

指導教授 ： 許國堂

中山醫學大學/醫學院/醫學研究所/碩士(2014年)

https://doi.org/10.6834/CSMU.2014.00111

摘要

利用金屬材料做成的人工髖關節，應用於關節置換手術是當前的骨科治療主流。但是金屬材料人工髖關節因其較大的彈性模數，置入人體後，產生應力遮蔽效應並導致人工髖關節在股骨骨髓腔中鬆動滑落。
除了無菌鬆落外，金屬材料人工髖關節置入人體後會釋放金屬微粒與離子至體內，進而導致發炎。為避免應力遮蔽效應、鬆落及發炎等不良反應，採用非金屬材料製造人工髖關節，是一項不錯的解決方案。
因此，本研究利用熱可塑聚氨酯(TPU)和氫氧基磷灰石(HA)複合材料，做成人工髖關節，並設計七項實驗來檢驗此新穎材質的生物相容性與機械性質。實驗結果發覺此複合材料具有潛力可發展成非金屬人工髖關節，完全無金屬成份的人工髖關節有益於年長患者，可避免因鬆落或發炎，對已置入人體的植入物，又再實施「再置換」手術的困擾。

關鍵字

人工髖關節 ； 生物相容性 ； 機械性質 ； 熱可塑聚氨酯 ； 氫氧基磷灰石

並列摘要

The implantation of Artificial Hip Joints (AHJ) that made by metallic material is the main stream of orthopedic surgery. Due to metallic implant devices have large elastic modulus, therefore, they produce Stress Shielding Effect and results in most of the metallic implants loosen in femur shaft.
Not only aseptic loosening may be occurred after long-term usage of the metallic implants, but also metallic implants release metal particles and ions to human body that may induce inflammation. To avoid such adverse responses, AHJ made by selected non-metallic material would be a better solution.
In this study, we use thermoplastic polyurethane (TPU) and hydroxyapatite (HA) composited material to make the AHJ . We have designed seven experiments to investigate the biocompatibility and mechanical properties of this novel AHJ composite material . We found that the composite material maybe developed as whole non-metallic artificial hip joint and be benefit to those elder patients and prevent them suffer prosthesis revision again.

並列關鍵字

Artificial Hip Joint ； Biocompatibilities ； Mechanical Properies ； Thermoplastic Polyurethane ； Hydroxyapatite

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