代謝症候群患者血漿輔酶Q10、維生素A及維生素E與氧化壓力、抗氧化酵素活性相關性之探討

代謝症候群（metabolic syndrome，MS）是指在一個人身上出現多重代謝異常，增加心血管疾病的發生率與死亡率。本研究目的為了解代謝症候群與健康受試者血漿抗氧化維生素（輔酶Q10、維生素A及維生素E）濃度與氧化壓力指標（丙二醛，malondialdehyde，MDA）、抗氧化酵素活性﹝過氧化氫酶（catalase，CAT）、超氧歧化酶（superoxide dismutase，SOD）及麩胱甘肽過氧化酶（glutathione peroxidase，GPx）﹞之相關性。MS之判定依據行政院衛生署國民健康局（2007）公布之判定標準（MS組，n = 72）。健康受試者經體檢資料血液生化值於正常範圍內，做為non - MS組（n = 105）。測量受試者血漿輔酶Q10、維生素A、維生素E、血脂質、MDA及抗氧化酵素活性。結果顯示MS組之血漿輔酶Q10及維生素E濃度顯著高於non - MS組；經三酸甘油酯校正後，血漿輔酶Q10及維生素E濃度則無顯著差異，但MS組之血漿維生素A濃度顯著低於non - MS組。MS組之抗氧化酵素活性皆顯著低於non - MS組；但MDA濃度兩組間無顯著差異。受試者之輔酶Q10濃度與SOD活性；維生素A及E濃度與GPx活性有顯著之正相關。本研究認為MS患者可能承受較高之氧化壓力，使抗氧化酵素及維生素A濃度有降低的情形。未來研究須進一步追蹤MS患者，其抗氧化維生素濃度是否隨體內代謝失衡的時間越久而有所改變。

關鍵字

輔酶Q10 ；維生素A ；維生素E ；抗氧化酵素；代謝症候群

並列摘要

Metabolic syndrome (MS) represents a cluster of physiological and anthropometric abnormalities. The purpose of this study was to investigate the relationships of coenzyme Q10, vitamin A and E, and antioxidant enzymes activities in subjects with MS. Subjects in the case group (n = 72) were according to the criteria for MS, defined by the Taiwan Bureau of Health Promotion, Department of Health (2007). The control group (n = 105) was comprised of healthy individuals with normal blood biochemical values. Plasma coenzyme Q10, vitamin A and E concentrations, lipid profiles, malondialdehyde (MDA) level, and antioxidant enzymes activities [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)] in Red blood cell (RBC) were measured. Subjects with MS had significantly higher concentrations of plasma coenzyme Q10 and vitamin E than those in the control group, but these differences disappeared after normalized for triglyceride level. The ratio of vitamin A to triglyceride and antioxidant enzymes activities were significantly lower in the case group compared with the control group. There was a significantly positive correlations between the levels of coenzyme Q10 and SOD (p < 0.01); vitamin A and GPx (p = 0.05); and vitamin E and GPx (p = 0.04) after adjusting for the potential confounders of MS. Subjects suffering from MS may be under a higher oxidative stress, resulting in low levels of antioxidant enzymes activities and vitamin A. Further studies are needed to evaluate antioxidant vitamins status in patients with long-term chronic MS.

並列關鍵字

coenzyme Q10 ； vitamin A ； vitamin E ； antioxidant enzymes ； metabolic syndrome

參考文獻

李奕瑋（民國93年）。父親嚼食檳榔是否會導致子女之代謝症候群提早發病？－以親子關係家族研究探討之。國立台灣大學預防醫學研究所碩士論文。

Abdilla N, Tormo MC, Fabia MJ, Chaves FJ, Saez G, Redon J. Impact of the components of metabolic syndrome on oxidative stress and enzymatic antioxidant activity in essential hypertension. J Hum Hypertens 2006;21:68-75.

Aberg F, Appelkvist EL, Dallner G, Ernster L Distribution and redox state of ubiquinones in rat and human tissues. Arch Biochem Biophys 1992;295:230-234.

Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome--a new worldwide definition. Lancet. 2005;366:1059-1062

Alleva R, Scararmucci A, Mantero F, Bompadre S, Leoni L, Littarru GP. The protective role of ubiquinol-10 against formation of lipid hydroperoxides in human seminal fluid. Mol Aspects Med 1997;18:S221-228.

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代謝症候群患者血漿輔酶Q10、維生素A及維生素E與氧化壓力、抗氧化酵素活性相關性之探討

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