第一部份：深層海水對餵食高膽固醇小白鼠心臟異常的改善效果 第二部份：抗氧化中藥厚朴萃取物在皮膚疾患之應用

Effects of Deep-Sea Water on Cardiac Abnormality in High-Cholesterol-Dietary Mice Applications of Chinese Herbal Medicine Magnolia for Dermatologic Disorders

沈瑞隆(Jui-Lung Shen)

指導教授 ： 鄭雅文 ； 周明智

中山醫學大學/醫學院/醫學研究所/博士(2011年)

https://doi.org/10.6834/CSMU.2011.00116

摘要

第一部份
實際應用
深層海水已廣泛被應用於很多方面，包括水產養殖、農業、食品製程、化妝品與醫學等等，近來我們更已經證實飲用深層海洋電解透析水可以有效降低血清脂質、血壓以及改善血液中各種膽固醇的比例，本研究更進一步發現深層海洋電解透析水可以保護餵食高膽固醇食物之小白鼠的心肌結構、左心室的細胞程序凋亡、增加心肌細胞存活信息如胰島素樣-1受體、PI3激酶與p-AKT/AKT比例 總體而言，綜合以上發現深層海洋電解透析水對心肌有保護作用，在潛在的多種市場中，可以運用於開發做為保護心臟之健康飲食的食品添加物。

第二部份
中藥在東方醫學仍然廣泛地被應用為重要的醫療用途。在最近幾年中，各種中藥的生物活性成份已被分離純化，並在研究實驗中被確認具有多種生理調節功能。「和厚朴酚」是一種由木蘭屬植物分離出的小分子植物多酚。它伴隨著其他相關多酚類包括「厚朴酚」等一同被發現，並具有相似的一些生理活性功能。近年來，和厚朴酚與厚朴酚在臨床前模式被發現具有抗氧化，抗發炎，抗腫瘤，抗微生物等作用，同時不具明顯的毒性。這些發現使得和厚朴酚與厚朴酚具有新的治療藥物開發潛力。在本論文中，我們對和厚朴酚與厚朴酚的近期實驗成果加以調查研究，並對於其可能的分子機制進行了描述。對於和厚朴酚與厚朴酚知識的多加了解，可以協助發展抗氧化中藥厚朴衍生物與臨床試驗的設計，未來有機會將和厚朴酚與厚朴酚應用在臨床皮膚疾患的治療上。

關鍵字

海洋深層水 ； 心臟異常之改善 ； 心臟保健 ； 美容醫療

並列摘要

Part 1
PRACTICAL APPLICATIONS
Deep-sea water (DSW) has been applied on several fields including aquaculture, agriculture, food processing, cosmetics, and medicine. Recently, we have indicated that high-cholesterol dietary mice drinking ED-DSW showed decreased serum lipids, blood pressure and improving blood cholesterol profile. In this study, we further demonstrated the beneficial effects of ED-DSW on high-cholesterol-dietary mice by reducing abnormal cardiac architecture, apoptosis in left ventricle and increasing cardiac survival signaling, such as insulin-like growth factor-1 receptor (IGF-1R), phosphoinositide-3-kinases (PI3K) and p-AKT/AKT ratio. Altogether, these findings indicated that ED-DSW revealed the cardiac protective effects and might be suggested as an ingredient of cardiovascular health food in a variety of niche markets.

Part 2
Chinese herbs have been and still are widely used as important remedies in Oriental medicine. Over the recent years, a variety of biologically active constituents have been isolated from these sources and confirmed to have multifunctional activity in experimental studies. Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. It is accompanied by other related polyphenols, including magnolol, with which it shares certain biological properties. Recently, honokiol and magnolol have been found to have anti-oxidative, anti-inflammatory, anti-tumor, and anti-microbial properties in preclinical models, without appreciable toxicity. These findings have increased interest in bringing honokiol and magnolol to the clinic as novel therapeutic agents in dermatology. In this review, the findings concerning the major mechanisms of action of honokiol and magnolol are described. Knowledge of the multiple activities of honokiol and magnolol can assist with the development of honokiol and magnolol derivatives and the design of clinical trials that will maximize the potential benefit of honokiol and magnolol in the patient setting for dermatologic disorders.

並列關鍵字

Deep Sea Water (DSW) ； serum lipid ； blood pressure ； apoptosis ； cardiac survival

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