以加速磨耗試驗探討關節液成份分子對人工關節材料磨耗顆粒形貌之影響

The Effects of Synovial Fluid Compositions on the Morphology of Wear Particle in Artificial Joint Materials by Accelerated Wear Testing

王賢傑(Hsien-Chieh Wang)

指導教授 ： 方旭偉

國立臺北科技大學/工程學院/化學工程研究所/碩士(2007年)

https://doi.org/10.6841/NTUT.2007.00157

摘要

人工關節的超高分子量聚乙烯（UHMWPE）元件壞損有兩個主要的原因，一個是UHMWPE 與金屬對磨的應力使其耗損，另一方面，UHMWPE 的磨耗顆粒會在人體內引發激烈的免疫反應，進而引發骨溶解（osteolysis）現象，最後造成人工關節鬆脫損壞。而將人工關節再置換手術時所取出的關節液與正常人的比較後，發現關節液的濃度與組成都有改變，因此為了減少磨耗及增加人工關節的壽命，我們針對不同濃度成份的關節液分子如何影響人工關節的磨潤性質來做探討。
故本研究利用半導體中的微米製程（microfabrication）製作微米加工表面（surface texture），加工表面上設計有微米尺寸的切割裝置（cutting device），藉由此裝置我們可以將UHMWPE 與加工表面進行加速磨耗試驗，並添加不同濃度的關節液分子溶液如白蛋白（albumin）、球蛋白（globulin）與磷脂質（phospholipids），探討其濃度變化對UHMWPE 磨耗行為的影響。
結果發現高濃度下的白蛋白、球蛋白與磷脂質溶液，所得到的UHMWPE 磨耗顆粒長度與寬度皆縮小，但是磨耗量卻分別有不同的變化，且高濃度下關節液分子所產生的磨耗顆粒長度、寬度皆比生理食鹽水小；為了進一步了解產生此磨耗現象的原因，使用微摩擦磨損測試機對滴有不同濃度組成關節液分子的UHMWPE 表面進行刮痕試驗，並比對先前磨耗實驗的結果，推測可能影響UHMWPE 磨耗顆粒產生機制的因素為何。

關鍵字

超高分子量聚乙烯 ； 磨耗顆粒 ； 加工表面 ； 關節液分子

並列摘要

Two major factors result in the malfunction of UHMWPE components in the artificial joints: the mechanical force of metal sliding against UHMWPE and the wear debris of UHMWPE. The wear particle of UHMWPE induce the immunological responses in the surrounding tissues, causing the osteolysis and even the aseptic loosening of artificial joints. The composition of the synovial fluid sampled during the revision surgeries differs from that of normal synovial fluid. In order to decrease wear rate and to extend the lifetime of artificial joints, we investigate the influence of synovial fluid composition on tribological behaviors.
In this study, we applied micro-fabricated surface texture to rub against the UHMWPE to accelerate the wear rate of UHMWPE. By changing the concentration of the lubricants, such as albumin, globulin, and phospholipids, we can observe the effects of lubricant concentrations on the wear behaviors.
When the concentration of albumin, globulin, and phospholipids was higher, the wear particles show shorter length and width, compared with PBS, but the wear amounts were different. In order to understand the wear mechanism, scratch tests were applied to UHMWPE lubricated with synovial components of varying concentrations. We thus discuss the mechanism of wear debris generation through the results of wear and scratch tests.

並列關鍵字

UHMWPE ； wear particle ； surface texture ； albumin ； globulin ； lipids

參考文獻

蘇毓智，生物潤滑液對超高分子量聚乙烯磨耗行為之影響，碩士論文，國立台北科技大學生物科技研究所，台北，2005。

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