表面接枝於磁性DP生醫陶瓷表面以葉酸標的腫瘤熱治療之研究

Folic Acid Immobilized Ferrimagnetic DP-Bioglass to Target Tumor Cell for Cancer Hyperthermia

陳民樺(Min-Hua Chen)

指導教授 ： 許淙慶 ； 林峰輝 ； Leszek Stobinski

國立臺北科技大學/工程學院/材料及資源工程系所/碩士(2006年)

https://doi.org/10.6841/NTUT.2006.00150

摘要

無資料

關鍵字

DP生醫陶瓷 ； 葉酸 ； 聚乙二醇 ； 表面接枝

並列摘要

DP-bioglass is one of biodegradable glasses, which can be used as bioactive material in soft tissue and bone. It was often used in orthopedic and plastic surgery. Recently, bioglass was also used as a carrier for drug and gene delivery systems. Additionally, ferrimagnetic DP-bioglass can be potential candidates for magnetic induction hyperthermia, by using a magnetic field. The aim of this work is the preparation and characterization of surface-modified ferrimagnetic DP-bioglass. First DP-bioglass has to be surface-modified with polyethylene glycol (PEG) and folic acid (FA) to improve its intracellular uptake and ability to target specific cells. PEG-FA complex was synthesized using carbodiimide (DCC) to link PEG with FA. Then PEG-FA complex were immobilized on the surface of DP-bioglass by using amino-silane (AEAPS) as a coupling agent. Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (1H NMR), and thermogravimetric analysis (TGA) was used to demonstrate this immobilization process. The biological study showed that immobilized ferromagnetic DP-bioglass with PEG-FA was non-cytotoxicity and significantly enhanced the intracellular uptake of DP-bioglass by target cells.

並列關鍵字

Ferrimagnetic ； DP-bioglass ； polyethylene glycol ； folic acid ； immobilization

參考文獻

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