添加異麥芽寡醣管灌配方對慢性臥床並使用呼吸器病人腸道功能及菌相之影響

The effects of isomalto-oligosaccharide supplement tube-feeding on intestinal functions and microflora in chronic bedridden patients with respirators

洪若樸(Raw-Pou Hung)

指導教授 ： 趙振瑞

臺北醫學大學/公共衛生暨營養學院/公共衛生學研究所/碩士(2012年)

https://doi.org/10.6831/TMU.2012.00115

摘要

本研究目的在添加異麥芽寡醣(isomalto-oligosaccharide, IMO)管灌配方對慢性臥床並使用呼吸器病人腸道功能及菌相之影響。招募受試者為20位大於45歲，使用鼻胃灌食。以隨機交叉試驗模式進行實驗，給予調整灌食配方(Isocal HN+Jevity HN Abbott)一星期後，其中10位受試者每日早上給予添加10公克異麥芽寡醣之灌食配方，其餘10位受試者則給予不添加異麥芽寡醣之灌食配方，持續4星期後，連續2星期排空期，之後原本給予添加之受試者換成不添加，而給予不添加者則給予另外添加異麥芽寡醣持續4星期。分別於第-1（實驗前）、0、2、4、6、8、10週，收集血液、糞便樣本進行分析。並紀錄腸胃功能特性，結果顯示，經添加異麥芽寡醣於第4、10週後分析結果發現血紅素、白蛋白、糞便的重量、含水量、乳酸桿菌數及雙叉桿菌數都有顯著增加（p＜0.05）；同時也發現糞便產氣莢膜梭菌數有顯著減少（p＜0.05）。由以上結果得知，添加異麥芽寡糖可以增加腸道有益菌雙叉桿菌，改善人類的腸道菌相，增加乳酸桿菌數、減少產氣莢膜梭菌數、有助於排便。

關鍵字

異麥芽寡糖腸道菌相 ； 乳酸桿菌 ； 雙叉桿菌 ； l產氣莢膜梭菌

並列摘要

The study was to examine the effects of isomalto-oligosaccharide (IMO) supplement tube-feeding on intestinal functions and flora in chronic bedridden patients with respirators. Twenty subjects aged of 45 years old or above with tube feeding were recruited for the randomized crossover study. One week after given Isocal HN and Jevity HN Abbott formula, 10 subjects were given tube feeding with 10 g IMO supplement every morning for 4 weeks, and switched to tube feeding without IMO supplement for 4 weeks after 2-week washout period, and vice sersa for other 10 subjects. Blood and feces samples were collected one week before the experiment, at week 0, 2, 4, 6, 8, and 10 for further analyses, and gastrointestinal function was recorded. Results showed that blood hemoglobin, albumin, fecal weight, water content, the amount of Lactobacillus and Bifidobacterium in the feces were significantly increased in the subjects given tube feeding with IMO supplement at week 4 and 10 (p＜0.05). However, the amount of Clostridium perfringens was decreased (p＜0.05). Therefore, IMO supplement enhances intestinal probiotics Bifidobacterium, increases the amount of Lactobacillus, decreases the amount of Clostridium perfringens, and improves fecal excretion.

並列關鍵字

isomaltose oligosaccharide (IMO) ； intestinal microflora ； Lactobacillus ； Bifidobacteria ； Clostridium perfringens

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