台東地區酒精性肝臟疾病患者體內抗氧化狀態之研究

Study of antioxidative status in Taitung area patients with alcoholic liver disease

陳麗如(Li-Ju Chen)

指導教授 ： 楊素卿

臺北醫學大學/公共衛生暨營養學院/保健營養學研究所/碩士(2008年)

https://doi.org/10.6831/TMU.2008.00078

摘要

本研究於馬偕紀念醫院台東分院招募27位酒精性肝臟疾病患者(alcoholic liver disease, ALD)，對照組則是依照ALD組經年齡及性別配對後募集之正常健康成人22位。分別針對此兩組受試者進行血液生化值、及抗氧化能力分析。結果發現與健康成年人比較之下，在血脂質方面，酒精性肝臟疾病患者總膽固醇 (total cholesterol, TC)、高密度脂蛋白膽固醇 (high density lipoprotein-cholesterol, HDL-C) 及低密度脂蛋白膽固醇(low density lipoprotein-cholesterol, LDL-C) 顯著低於對照組 (p<0.05)，而三酸甘油酯（triglyceride, TG）濃度方面兩組無顯著差異。另一方面，ALD患者紅血球中之抗氧化酵素超氧化歧化酶 (superoxide dismutase, SOD)、過氧化氫酶 (catalase, CAT)活性顯著下降 (p<0.05)，而且紅血球中還原型與氧化型麩胱甘肽含量比值 (GSH/GSSG) 顯著下降 (p<0.05)，但血漿脂質過氧化物 (thiobarbituric acid reactive substances, TBARS) 濃度則沒有顯著差異。

關鍵字

酒精性肝臟疾病 ； 抗氧化酵素 ； 台東

並列摘要

This study recruited 27 patients with alcoholic liver disease (ALD) in the Taitung Mackay Memorial Hospital, and 22 healthy adults who matched the age and sex of ALD patients as the control group. The clinical data and antioxidant capacity were investigated. Compared with the control group, the total cholesterol (TC) and high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) concentrations were significantly decreased in ALD patients (P<0.05). However, there were no differences in the triglyceride (TG) concentration between the ALD patients and the health adults. Compared with the control group, the superoxide dismutase (SOD) and catalase (CAT) activities and GSH/GSSG ratio in the erythrocyte were significantly decreased in ALD patients (P<0.05). However, there were no differences in the plasma thiobarbituric acid reactive substances (TBARS) concentration between the ALD patients and the health adults.

並列關鍵字

alcoholic liver disease ； antioxidative enzyme ； Taitung

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