Taiwan’s high performance in the semiconductor industry is due to a cluster effect and completed competition However, Taiwan has to change styles from manufacturing to a knowledge based economy to survive and compete in the world market because China’s competence for low cost manufacturing cannot be ignored. The value chain of the semiconductor industry is long, but the virtual re-integrated supply chain leads Taiwan to excel in each stage of the value chain. This industrial cooperation model provides a beneficial environment for IC design activities because it is difficult for entrepreneurs to have enough capital to build wafer manufacturing plants to commercialize innovations. IC design is one of the focused knowledge economies in Taiwan, so there are many IC design startups created to seize opportunities because of innovations. The two most popular kinds of IC design startups in Taiwan are talent buy-in and spin-offs. Per the researcher’s observation, the success rate for spin-offs is higher than talent buy-ins, so the objective of this research was to identify the competence in marketing, human resource, innovation, manufacturing, and finance for IC design spin-offs to excel in the global semiconductor industry. This research uses the spin-offs excel model to measure spin-offs, and evaluates the model using a case studies research method. In the case studies of this research, expert opinions were sought through in depth interviews with three representative control and experimental groups. How are spin-offs able to leverage the parent company to succeed in the market place? This research found that spin-offs can receive competence in marketing, innovation, and manufacturing when leverage with the parent company exists. No distinct competence in HR and finance exists according to the research. This research provides recommendations for solving problems related to startups and spin-offs.