本研究是以自組裝超分子結構的金屬錯合配位基三吡啶( TPY )來建構出含生物素( Biotin )的過渡金屬超分子共聚物。而為了將三吡啶接在高分子鏈上,因此藉由取代反應與酯化反應改質三吡啶末端基,並合成可逆加成-斷裂鏈轉移自由基聚合法( RAFT )所需的鏈轉移試劑( CPDB & EOSPE ),經由FTIR與1H-NMR鑑定分析其結構。再將改質的三吡啶、甲基丙烯酸甲酯( MMA )與異丙基丙烯醯胺( NIPAM )與鏈轉移試劑,經RAFT聚合法,聚合成改質聚合物 ( PMMAMATPE & PNIPAM-TPY )。將改質後的NH2-TPY改質生物素,合成含生物素的三吡啶衍生物( BIOTIN-TPY ),由FTIR、1H-NMR與UV-vis鑑定分析結構,以及利用GPC、DSC與TGA鑑定分析聚合物的熱性質與光學性質。最後,再利用過渡金屬離子與配位基所產生的金屬-配位作用力,將PMMAMATPE、PNIPAM-TPY分別與Biotin-TPY進行金屬配位錯合鍵,製備出具生物活性分子之生物素金屬超分子共聚物,鑑定其結構並研究其物質特性。
The synthesis and characterization of self-assembly supermolecular structure of terpyridine containing biotin and side-chain or end modified polymers were performed in this study. The substitution modification was made to graft terpyridine on the polymer chain, with the esterification of terminal group of terpyridine. The chain transfer agents ( CPDB & EOSPE-TPY ) for reversible addition-Fragmentation chain transfer polymerization were synthesized and characterized by FT-IR and 1H-NMR. The modified terpyridine moiety, methyl methacrylate ( MMA ), and N-isopropylacrylamide ( NIPAM ) were copolymerized by RAFT polymerization. Furthermore, the biotin modified terpyridine derivative was synthesized by NH2-TPY. The structure characterizations were conducted by FT-IR, 1H-NMR , UV-vis spectra and GPC. The DSC and TGA were also used to analyze the thermal properties of polymer. Finally, the metallo supermolecular polymer will be prepared using the metal-coordination interaction to self-assemble the terpyridine derivatives.