利用高價碘(III)試劑進行Dienones、α, β-不飽和Weinreb amides及α-Hydroxyketones的合成研究

Hypervalent Iodine(III) Reagent Mediated Synthesis of Dienones, α, β-unsaturated Weinreb amides and α-Hydroxyketones

黃姵文(Pei-Wen Huang)

指導教授 ： 陳麟慶

高雄醫學大學/藥學院/藥學研究所/碩士(2003年)

摘要

近年來，由於高價碘試劑具有低毒性、易處理的特質，所以被廣泛地應用於有機合成上。而其中以phenyliodine(III) diacetate (PIDA)、phenyliodine(III) bis(trifluoroacetate) (PIFA)與[hydroxy(tosyloxy)iodo]benzene (HTIB)為最常被使用的幾種高價碘試劑。在本研究中，我們計劃分別利用高價碘試劑PIDA、PIFA與HTIB來進行dienones、α,β-不飽和Weinreb amides和α-hydroxyketones的合成研究。

關鍵字

高價碘(III)試劑

並列摘要

In recent years, hypervalent iodine reagents have attracted much attention as useful synthetic reagents. These hypervalent iodine reagents have been extensively used inorganic synthesis due to their low toxicity and easy handling. In the family of hypervalent iodine compounds, phenyl iodine(III) diacetate(PIDA), phenyliodine (III) bis(trifluoroacetate) (PIFA) and [hydroxy(tosyloxy)iodo]benzene (HTIB) are the most frequently used and easily available reagents. In this work, PIDA, PIFA, and HTIB will be applied to prepared dienones, α,β-unsatured Weinreb amides and α-hydroxyketones.

並列關鍵字

Pummerer reaction

參考文獻

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