營造業勞動者常飲用之酒精性飲料對大白鼠健康影響評估

The study on the effect of the most popular alcoholic drinks among construction worker in Wistar rat

陳嬿琦(Yen-Chi Chen)

指導教授 ： 陳振和

長榮大學/健康科學學院/職業安全與衛生研究所/碩士(2008年)

https://doi.org/10.6833/CJCU.2008.00007

摘要

本研究的主要目的係針對營造業勞動者每日工作前最常飲用的酒精性飲料，進行動物實驗評估健康之影響。實驗採用2個月的公大白鼠(Wistar strain)，可自由進食及飲水。每天以餵食管灌食5 ml飲料：控制組餵食水，實驗組則分組餵食酒精性飲料，包含兩種不同品牌的含酒精成份提神飲料、米酒及兩者的混合物。紀錄其體重變化，並於開始餵食後的2、3、4、5、6個月後進行活動力與平衡測試，測試完即犧牲，先抽取心臟血液進行生化檢測，再取其各部位組織進行切片以作病理分析。初步結果發現酒精性飲料在長期服用下將造成且活動力增加，但大白鼠體重增加稍顯遲緩，血液中三酸甘油脂濃度偏高。經由肝臟組織切片檢查，發現飲用酒精性飲料，將使肝臟產生些微的變化，經由HE染色觀察，肝細胞呈現壞死的比例有上升的趨勢，且組織中有少數區域也出現白血球浸潤 (polymorphonuclear infiltrate) 的現象。

關鍵字

營造業勞動者 ； 酒精性飲料 ； 動物實驗

並列摘要

Our main objective was to evaluate the health effect of two popular alcoholic drinks among construction workers in Taiwan. Male Wistar rats (8 weeks old) were randomized and divided into 4 groups. They were fed (5ml / once a day) via a nasogastric tube with: 1) water, 2) A brand of alcoholic liquors, 3) B brand of alcoholic liquors, 4) rice brewing alcoholic liquors. All the rats received water and food ad libitum. The body weight was monitored daily. After 3, 4, 5 - month period, rats in each group were tested for locomotion activity and balance analysis before sacrificed. Then the blood samples were drawn and several organs were removed for biochemical and pathological analysis, respectively.
The preliminary data reveals that rats after long-term exposures to both alcoholic liquors will increase in locomotor activity, and have tendencies to retard grow and increase on their blood triglyceride.

並列關鍵字

construction workers ； alcoholic beverage ； animal assays

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