以單頻生物阻抗分析法研究人體水分含量

本論文在研究臨床上如何掌握病患體液的變化，期能對於許多疾病的治療及預後評估有助益。臨床上液體狀態評估有不同的方法。在眾多的測量人體的水分含量指標的臨床人體組成測定方法中，生物電阻抗分析法具有簡便、快速、非侵入性及準確的優點。本論文以利用生物電阻抗分析法的方式，研究開發簡易系統達到身體總水分含量(Total body water)、心律(Heart rate)的狀態量測與現象。並與市面上的品牌體脂計相比，量測雙手與雙腳部位的身體內總水分含量，以及經由量測胸部阻抗的變化，與心電圖訊號及光體積變化描記圖相比較。本論文在雙手量測與雙腳量測身體總體水分變化方面在喝水後，身體的總體水分含量會先下降，經過一段時間後會再上升。身體總水份量測系統與市售體脂計在數據上的相關係數有0.87與0.92。在胸部阻抗變化量測結果數據中，與心電圖訊號的比較在心律分析部分，相關係數有0.9263 。初步證實本論文開發的量測系統於身體總水分含量參數及心律參數的可行性。在未來能改進電路再微小化、更精準解析小訊號，並能分析出各種相關參數，達到預防及控制的功能。

關鍵字

心律；身體總水分含量；生物電阻抗分析法

並列摘要

The purpose of this research was to study the way to monitor the change of patients’ body fluid hoping to assist treatments and prognosis of many diseases. Clinically, there are many methods to evaluate the condition of body fluid. Among various body water content indicators of clinical human body composition estimations, bioelectrical impedance analysis is non-invasive, accurate, and the simplest and fastest. In this study, biological impedance analysis was used to develop a simple system to measure the condition of total body water content and heart rate. The results of measuring both hand backs and insteps were also compared with of which from a commercial body fat monitor. Moreover, the results of thorax impedance change were compared with Electrocardiography (ECG) and Photoplethysmography (PPG). The total body water contents acquired from measuring both hand backs and insteps after water intake decreased first but increased after a period of time. The correlation coefficients of the total body water content measuring system and the commercial body fat monitor were 0.87 and 0.92. In the comparison of heart rate analysis results of thorax impedance change and ECG, the correlation coefficient was 0.9263. The preliminary results have proved the feasibility of the proposed system in measuring total body water content and Heart rate parameters. In the future, it is expected that miniaturized circuits and more accurate small signal analysis are developed to analyze different parameters to achieve the ability in prevention and control.

並列關鍵字

heart rate ； Bioelectrical impedance analysis ； total body water

參考文獻

[5] 鍾承穎、洪啟智、黃尚志、陳鴻鈞， ”生物阻抗分析於內科學之應用”，內科學誌,2012

[1] Robert F Kushner, MD and Dale A Schoeller, PhD, “Estimation of total body water by bioelectrical impedance analysis”, The American Journal of Clinical Nutrition,1986

[2] Ursula G. Kyle et al. “Bioelectrical impedance analysisFpart I: review of principles and methods”, Clinical Nutrition,2004

[4] Hermann L. Ueber eine. “Wirking galvanischer Strome auf Muskeln and Nerven.” Pflugers Arch gesamte Physiol,1871.

[7] Wang ZM et al, “The five-level model:a new approach to organizing body-composition reseach.” Am J Clin Nutr, 1992.

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以單頻生物阻抗分析法研究人體水分含量

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