中孔洞二氧化矽包覆防曬劑之製備與性質研究

The Study of Preparation and Performance of UV Filter Encapsulated by Mesoporous Silica

李佳晉(Chia-Ching Li)

指導教授 ： 陳玉惠

中原大學/理學院/化學研究所/博士(2016年)

https://doi.org/10.6840/cycu201600015

摘要

本研究之目的是利用中孔洞二氧化矽(MS)做為防曬劑的載體，利用包覆的方式用以改善防曬劑之防曬能力及降低皮膚滲透。由於人們對於紫外線會造成人體不良影響之意識逐漸提高，使得防曬產品的使用率不斷增加，但根據許多研究指出，目前使用的防曬劑可能會滲透或利用經皮吸收方式進入人體皮膚，而引起一些不良反應，如光毒性和光過敏反應。本次研究利用溶膠凝膠法，製備中孔洞二氧化矽單獨包覆BP-3型或同時包覆BP-3與OMC複合型防曬劑，分別將其命名為BESs (BES-1及BES-2)及S4M1B1，之後利用FTIR、TGA及DSC等儀器，進行樣品之性質鑑定與分析，結果顯示各樣品中防曬劑的包覆率分別為34wt% (BES-2), 45 wt % (BES-1) 及52wt% (S4M1B1)。而利用體外測試測得含有BES-2之防曬乳液(BES-2-E)，其防曬係數SPF及UVA-PF，比添加未包覆BP-3之防曬乳液(BP-3-E)，分別高出2倍及1.64倍，且經過三個月的存放，BES-2-E的防曬能力維持效率，比BP-3-E高出7-8倍。而含有S4M1B1之防曬乳液(S4M1B1-E)，同樣較添加未包覆之BP-3與OMC的防曬乳液(S4M1B1-Mix-E)，具有較高的SPF及UVA-PF，分別增加1.4倍及1.3倍。至於，利用Franz glass diffusion cell方法，所測得之防曬劑皮膚滲透量，其結果顯示，利用MS作為載體包覆後的防曬劑BP-3及OMC，調製成防曬乳液後，均能有效降低兩種防曬劑的皮膚滲透率，此結果對於防曬乳液是相當重要的，因為防曬劑一旦滲透進入皮膚，將失去其防曬效果，且對皮膚會造成危害。本研究結果證實，利用MS包覆之防曬劑BES-2及S4M1B1，未來可添加於防曬化妝品中，增加使用者的安全性與有效性。

關鍵字

中孔洞二氧化矽(MS) ； 防曬劑 ； 防曬化妝品 ； 皮膚滲透 ； 載體

並列摘要

The aim of this study was to improve the UV protection ability and reduce the skin penertration of the UV-filters with mesoprous silica (MS) as drug carrier by encapsulation method. The use of sun protection products is constantly increasing due to the result of recognition and increased public awareness of the adverse effects of UV solar radiation. Even so, studies have shown that currently used sunscreens can cause adverse reaction such as phototoxic and photoallergic reactions, owing to their penetration into the viable cutaneous strata and to transdermal absorption. In this study, various amounts of benzophenone-3 (BP-3) alone or together with octyl methoxycinnamate (OMC), were encapsulated in mesoporous silica (MS) to form the BP-3 encapsulated or BP-3/OMC co-encapsulated UV-filters, namely, BESs (BES-1 and BES-2) and S4M1B1, respectively, via in-situ sol-gel process. The characterization of BESs and S4M1B1 were carried out with fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The results showed that the amount of the UV filters encapsulated in MS was about 34wt%, 45%and 52wt% for BES-2, BES-1 and S4M1B1, respectively. On the other hand, BES-2 containing emulsion (BES-2-E) exhibited about 2 times and 1.64 times higher SPF and erythemal UV-A PF values, respectively, and after 3 months about 7-8 times higher protection retention capability than the free BP-3 containing emulsion (BP-3-E). Besides, S4M1B1 containing emulsion (S4M1B1-E) exhibited about 1.4 times and 1.3 times higher SPF and erythemal UVA-PF values than the corresponding free BP-3 and OMC containing emulsion (S4M1B1-Mix-E), respectively. Moreover, the result of the in vitro skin penetration test using Franz glass diffusion cell indicating that the skin permeation of BP-3 from BESs or BP-3 and OMC from S4M1B1-E is lower than that from nonencapsulated BP-3-E and S4M1B1-Mix-E. This property is particularly important for sunscreens because the amount of sunscreen penetration inside the stratum corneum directly correlates to its UV protection ability, and avoiding a direct contact with skin and reducing the harm to skin. The results of this study demonstrate that the as-prepared MS used as a carrier for BP-3 alone or together with OMC significantly increased efficacy and safety of the sunscreen.

並列關鍵字

mesoprous silica (MS) ； UV-filters ； sunscreens ； skin penetration ； carrier

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