不具有傳統pH 應答部位的可逆型pH 刺激應答醣脂質水凝膠因子

The Reversible pH-Stimulative Hydrogelators Based on Glycolipid without Possessing Conventional pH-Responsive Moieties

黎俊廷(Jyun-Ting Li)

指導教授 ： 蔡祐輔

中原大學/理學院/化學研究所/碩士(2015年)

https://doi.org/10.6840/cycu201500947

摘要

本論文，已開發出兩個低分子量水凝膠因子。其組成結構，分別
為具有(2S,3S)-2,3-二羥基十烷酸，及(2R,3R)-2,3-二羥基十四烷酸的葡
萄醣胺醣脂質(分別為S10 及R14)。在此二化合物中，S10 在pH 3.0-5.0，可展現刺激應答的功能，為一可逆型的凝膠因子。
有關此二羥基烷酸的不對稱合成，我們採用掌性池塘(chiral pool)
策略給予完成。在此，我們以D-核醣(D-ribose)為起始物，可同時完
成立體組態互為鏡像的此二光學活性二羥基烷酸。

關鍵字

水凝膠因子 ； pH 應答 ； 醣脂質

並列摘要

Two low molecular weight hydrogelators have been developed by us.
These two hydrogelators are the glycolipids that consist of glucosamine,
tethering the (2S,3S)-2,3-dihydroxydecanoyl acid and (2R,3R)-2,3-
dihydroxy tetradecanoyl acid, respectively.(S10 and R14). Among these two compounds, S10 a reversible gelator exhibits the stimulus-responsive ability at pH 3.0-5.0.
The asymmetric synthese of these two dihydroxyalkanoyl acids have been accomplished by using chiral-pool method strategy. Herein, D-ribose is used as the starting material to synthesize these two optically active
dihydroxyalkanoyl acids that configurations are mirro image each other at the same time.

並列關鍵字

Hydrogelators ； pH-Stimulative ； Glycolipid

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