一氧化氮是一種關鍵的信號分子,在生物體內具有的重要功能性:包含血管舒張、神經傳導、血壓調控、毒殺外來病原體甚至可抗腫瘤等。然而一氧化氮為活潑氣態分子,半生期短,因此發展出能攜帶且釋放一氧化氮之化合物值得研究。 參考過去文獻中雙亞硝基鐵錯合物具有高穩定性及傳遞一氧化氮,本研究利用[Fe2(μ-1,2-MePyr)2(NO)4] 為起始物,與硫醇 (HSC2H4CO2H)反應成功合成雙亞硝基鐵錯合物 [Fe2(μ-SEtCOOH)2(NO)4],其IR吸收峰位於1776 s cm-1及 1751 s cm-1,而金屬有機骨架材料(MOF)具有合成簡單、穩定性強及對生物體低毒性等特點,我們利用Fe(NO3) 3.9H2O及Terephthalic acid快速合成金屬有機骨架複合材料(MIL-88B(Fe)) 作為雙亞硝基鐵錯合物之載體。 本研究成功將雙亞硝基鐵錯合物成功裝載入MIL-88B(Fe),其IR光譜吸收峰位於1777 s cm-1及 1751 s cm-1,未來應用在釋放一氧化氮的動力學及生物體內釋放一氧化氮之研究值得進一步探討。
Nitric oxide (NO) is a key signal molecule. It’s important in the creature, including vasodilation, neurotransmission, regulation of blood pressure, antipathogenic organism and anticancer. However, NO is an unstable gas molecule with short half-life, therefore it’s worthy to develop compounds that carry and release nitric oxide. Dinitrosyl Iron Complexes (DNIC) was reported for the delivery of NO. In this study, DNIC [Fe2(μ-SEtCOOH)2(NO)4] was successfully synthesized through reaction of DNIC [Fe2(μ-1,2-MePyr)2(NO)4] and thiol (HSC2H4CO2H) . DNIC [Fe2(μ-SEtCOOH)2(NO)4] shows IR absorption peaks at 1776 s and 1751 s cm-1. Metal-organic Frameworks (MOF) is a porous material which is synthetic friendly, stable and non-toxic to creature. In this work, we use Fe(NO3) 3.9H2O and terephthalic acid to synthesize (MIL-88B(Fe)) as carrier of dinitrosyl iron complex. Dinitrosyl iron complex was successfully incorporated into MIL-88B(Fe) according to the IR absorption peak at 1777 s and 1751s cm-1. Investigation of the kinetics for the release of nitric oxide from these materials are underway. Keywords: Nitric oxide、Nitric oxide donor、Metal -organic Frameworks