應用於生醫檢測之離子感測場效電晶體及信號處理電路晶片之研製

The Study and Fabrication of Ion-Sensitive Field-Effect Transistor and Signal Processing Circuit Chips for Biomedical Detection

郭家育(Jia-Yu Guo)

指導教授 ： 林明權

共同指導教授 ： 王瑞祿(Ruey-Lue Wang)

崑山科技大學/工程學院/電子工程研究所/碩士(2008年)

摘要

近年來，由於社會老年化及環境污染嚴重，疾病預防變成一重要的研究主題。人體內特定生物指標分子(如：肌酸酐、膽紅素…)的濃度與人體的特定疾病的發生有關。國科會已將生醫電子規劃為重點研究項目，希望能整合醫學、生化、電子電機、資訊…等專業人材，投入整合型研究。
本論文基於上述的發展趨勢，著重在研製離子感測場效電晶體(Ion-Sensitive Field-Effect Transistor－ISFET)及相關的信號處理電路，離子感測場效電晶體是一可與標準CMOS製程整合的元件結構，可以直接與信號處理電路整合成單一晶片。離子感測場效電晶體可以直接將生物指標分子的離子濃度轉換成對應的汲極電流。本論文研究及分析以分子式拓印高分子材料(molecular imprinted polymer－MIP)為感測薄膜的離子感測場效電晶體感測元件對生物指標分子的檢測機制及相關特性。為了能直接將信號處理電路與感測元件整合單一晶片，以數位電路及充放電機制為主的信號處理電路之設計也是本論文的重點。
我們已針對一些生物指標分子(如：肌酸酐、膽紅素…)建立分子濃度與感測物理量(ISFET汲極電流)間關係性，我們也設計出兩種信號處理電路。

關鍵字

離子感測場效電晶體 ； 分子拓印模板 ； 肌酸酐

並列摘要

Owing to social aging and the serious environment pollution, disease prevention has become an important research topic in recent years. It is known that the concentration of any specific biomarker in the human body is related to the occurrence of specific disease occurrence. The National Science Council (NSC) has already considered bioelectronics as an important research area. NSC hopes to integrate the experts in medicine, biochemistry, electronics, electric engineering, and information and so on to study the topic.
This thesis is based on the development tendency mentioned above. In this study, the ion-sensitive field-effect transistor (ISFET) and its related signal processing circuits were designed and fabricated. An ISFET is a structure that can be implemented by standard CMOS processes and be directly integrated into a single chip with its related signal processing circuits. An ISFET can directly transfer the ion concentration of a specific biomarker into the related drain current. In this thesis, a molecular imprinted polymer (MIP) is used as a sensing membrane for the ISFET. The detection mechanisms and related electrochemical characteristics are studied and analyzed. To integrate directly into a single chip with signal processing circuits, the design of signal processing circuits consisting of digital circuits and charge and discharge topologies also is the research topic of this thesis.
We have already aimed at some specific biomarkers such as creatinine and bilirubin. The relationships between molecular concentration and related physical quantity of the ISFET (i.e, drain current) have been obtained. In addition, two signal processing circuits have also designed.

並列關鍵字

ISFET ； MIP ； creatinine

參考文獻

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