This research is aimed to analyze the effects of different blade design factors on the performance of centrifugal water pump in order to obtain the optimum design to the blades. The velocity field of the working fluid and the performance curve of the numerical model established by CAD are calculated by using CFD software ADINA. In the simulation, the efficiencies of centrifugal water pump with different blade inlet angle, blade outlet angles, and blade number are also obtained and analyzed.