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  • 學位論文

化學物混合交互作用之再研究

A Re-visit of Assessment of Interactions in Chemical Mixtures

指導教授 : 陳鄰安

摘要


這篇文章目的在於提出較無爭議之化學物混合之效用的分解。我們提出此分解之母體主效用及交互作用。在常態分配之假設下我們計算這些作用並且以表格呈列,我們也進一步介紹統計估計方法,並模擬分析其估計效果。

並列摘要


This paper propose new but unambiguous systematic decompositions of the effect of covariates on a response variable into main effect and interaction effects. The population type main effects and interaction effects under the normal distribution are formulated. These effects under some examples of distributional parameter settings are computed and presented. Then, this settings make the study of main effects and interactions available through classical statistical inferences techniques.

參考文獻


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3.Ei-masri, H. A., Reardon, K. F. and Yang, R. S. H. (1997). Integrated approaches for the analysis of toxicologic interactions of chemical mixtures. Critical Reviews in toxicology,27,175-197.
4.Kifley, A., Liew, G., Wang, J. J., Kaushik, S., Smith, W. and Wong, T. Y. (2007). Long-team effects of smoking on retinal microvascular caliber. American Journal of Epidemiolopy,166,1288-1297.
5.Mumtaz, M. M., De rosa, C. T., Groten, J., Feron, V. J., Hansen, H. and Durkin, P. R. (1998). Estimation of toxicity of chemical mixtures through modeling of chemical interactions. Environmental Health Perspectives,106,1353-1360

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