The health care and drug safety are two important subjects for modern society. Recently, clinical medical research is especially paid attention to pharmacy control. In order to improve quality of life, it is necessary to investigate the difference between dosages or drugs. The goal of this paper is to test the marginal homogeneity having two dependent variables of matched pair data with three responses. Some well-known statistic methods are studied. Comparisons between those methods are conducted by simulation studies, and simple and suitable methods are recommended for practical applications.