利用4-羥基巴豆醛與硝基烯烴經由不對稱有機催化連續Michael-Henry 反應可合成出具有多取代環戊烷衍生物,且具有高鏡像選擇 性。另外也藉由X-ray 單晶繞射分析決定出其相對立體組態。
Asymmereic synthesis of highly functionalized cyclopentane ring, was carried out via organocatalyzed domino Michael-Henry reaction of 4-hydroxy crotonaldehyde and nitrostyrene at ambient temperature. However the cyclopentane adducts was obtained with high enantioselectivity and modrate diastereoselectivity. On the other hand the relative stereochemistry of major distereomer was determined by X-ray analysis.