光纖式多層膜表面電漿共振感測器之研究

THE STUDY OF SPR FIBER SENSORS BASED ON MULTI-LAYER STRUCTURE

許翔誌(Hsiang-Chih Hsu)

指導教授 ： 蔡五湖

大同大學/電機資訊學院/光電工程研究所/碩士(2009年)

摘要

表面電漿共振被廣泛的應用在化學及生物的特性和分子量級的交互作用測量上。傳統的表面電漿共振感測技術擁有高的靈敏度、動態變化的即時測量、以及在生物感測上無須標地等優點。光纖本身擁有體積小、成本低、並且和具有表面電漿共振理論相同架構。本論文結合光纖優點與多層膜微結構，可用來檢測介面上的折射率或薄膜厚度的微小變化。利用分析生物分子間的交互作用，將有助於新藥物的開發、疾病的快速檢測、與奈米生物學的發展。 本論文利用薄膜光學的概念來設計製作新式的SPR薄膜感測器，參考導納軌跡圖(Admittance Loci)的設計方法，來調變表面電漿共振感測器之吸收波長波段。利用介電質膜與金膜所製作而成的SPR光纖感測器，與傳統單層金膜SPR光纖感測器之比較，可將原本在600 nm-700 nm波段的表面電漿共振感測器之吸收波長，分別依照TiO2膜厚不同，將其調變至1037 nm-1141.4 nm、1186.2 nm-1301 nm、1295.4 nm-1445.2 nm、1410.2 nm-1571.2 nm。此結構改善將可解決光纖在量測有其適用波長之限制，並提高訊號的靈敏度與增大量測的範圍。此外，利用反射光強度變化可準確的量測不同濃度之酒精與葡萄糖之靈敏度可達2.55×10-6的折射率單位。

關鍵字

表面電漿共振 ； 光纖 ； 多層膜 ； 二氧化鈦

並列摘要

The phenomenon of surface plasmon resonance (SPR) is widely applied to the biological and chemical sensing for characterizing and quantifying bio-molecular interactions. The traditional advantages of SPR detective method have high sensitive response, kinetic sensing in real-time, and label-free for biological applications. Optical fiber sensors possess the characteristics of small, low cost, and the same scheme on conventional SPR technique. It is worthy to study and investigate the optical fiber SPR sensor. In this thesis, a multi-layer micro-structure is introduced to the optical fiber sensor for the tiny changes of the refractive index and film thickness measurments. By analyzing the inreractions of bio-molecules, the optical fiber sensor use proposed are useful for drug screening applications, high throughput analysis, diseases diagnosis, and the research of nano-biotechnology.
The concept of admittance locus for optical thin film design is applied to analyze the new multi-layer SPR fiber sensor for modulating the absorption in wavelength. Both the SPR fiber sensors with a dielectric thin film coated on the gold film, and the traditional single-layer gold film SPR fiber are carried out for DI water, alcohol, and glucose solutions detections, with the results of the SPR absorption in wavelength shifting from the original location of 600 nm-700 nm to 1037 nm-1141.4 nm, 1186.2 nm - 1301 nm, 1295.4 nm-1445.2 nm, 1410.2 nm-1571.2 nm, respectively, as the thickness of the TiO2 dielectric thin film has the value range from 1037 nm to 1571.2 nm. The SPR fiber sensors with a dielectric thin film coated on the gold film not only can enhance the sensitivity, but also can extent the measurements wavelength from visible light to the wavelength used in the optical fiber communications. In addition, the optical SPR fiber sensors we proposed will be applied is the measurements for different concentrations of alcohol and glucose solution with the sensitivity of up to 2.55 × 10-6 refractive index units.

並列關鍵字

spr ； fiber ； multi-layer ； TiO2)

參考文獻

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