Job shop problem is one of the most complex and difficult problem of combination of optimization, the purpose of this research is to increase production efficiency and lower down process time, so, it could get maximum profits. Advanced computer technology nowadays let artificial intelligence which means computation of simulated biological evolvements gradually be used on Job shop problem, also, this thesis in order to let Job shop problem could be used easily for public, so it combines comprehensive-used MS Project and apply genetic algorithm, and it brings up modified genetic algorithm to improve resource smooth function of original project, then it can shorten total factory hours, at the same time, Finally FT and LA testing subjects could verify credits of this thesis.