- 學位論文
電漿表面親水化對固定結冷膠的影響
Plasma hydrophilic modified substrate for immobiligation of Gellan Gum
摘要
本研究利用低溫電漿改質技術沉積IPA聚合膜或是以氧氣電漿處理於不同的基材上，探討表面親疏水性對於結冷膠固定量的影響，並進行生物相容性試驗，由水接觸角可以知道IPA電漿沉積膜的水接觸角不太受底材種類的影響，大約落在60~70度之間，以氧氣處理的基材水接觸角都可以達到10度以下，使用氧氣處理表面可使表面帶有許多過氧化的官能基，由AFM圖也可以看出粗糙度有明顯的增加，由於結冷膠的內聚力很強塗佈的時候經常無法得到均勻的薄膜，因此表面積與對水的親和增加可以使得結冷膠接觸角下降，讓表面的結冷膠可以均勻的塗佈在表面上也可以讓基材與結冷膠有較好的結合，經由細胞培養試驗以後可以發現IPA電漿鍍膜雖然不能有效提高與結冷膠的結合度，但可以有效的增加細胞貼附。
並列摘要
In this study, we use the low-temperature plasma modification technology to deposite thin film or activate the substrate surface. Explore the impact of plasma treatment on fixing Gellan gum.The water contact angle showed that after IPA plasma treatment the contact angle was improved to 60~70 degree, and after oxygen plasma treatment the contact angle was improved less than 10 degree. and oxygen plasma treatment can let surface connect with peroxide functional groups. The surface properties of TPU, glass, Al thin film were also characterized by electron spectroscopy for chemical analysis and scanning electron microscope. By the AFM images can seen that the roughness has increased after oxygen plasma treated. Because gellan gum has strong cohesion it is hard to get a uniform film on the surface, therefore, increase the surface hydrophilicity can decrease the contact angle of gellan gum, then we can get good combination of gellan gum with the substrate and uniform coating thin film on the surface. With the cell culture can seem IPA plasma can't effectively improve the combination of substrate and gellan gum but can effectively increase the cell-attached later via cell culture experiments.
參考文獻
延伸閱讀
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