純鈦和鈦合金是目前在醫學中被廣泛使用的生醫金屬材料。由於β鈦合金具有與骨頭較接近之楊氏模數,對骨頭傷害較小,於是許多研究朝向開發低剛性生醫β型鈦合金。本研究針對擁有良好機械性質的Ti-Cr合金與Ti-Zr合金,探討合金於含氟與不含氟之人工唾液中的耐蝕性質,並以SEM與ESCA觀察合金經腐蝕後之表面型態與腐蝕生成物分析。在生物適應性測試方面,以MG-63細胞培養於合金表面,利用SEM觀察細胞生長形態及MTT assay做定量生物適應性評估。實驗結果顯示,在不含氟人工唾液中,Ti-Cr合金與商業用?鈦 (c.p. Ti)之腐蝕電位 (Ecorr)和腐蝕電流 (Icorr)無顯著差異 (p<0.01),在含0.5 wt% NaF人工唾液中,Ti-30Cr之Ecorr值 (-1.03 V)高於c.p. Ti (-1.22V),Icorr值 (2.91 μA/cm2)低於c.p. Ti (62.51 μA/cm2),Ti-30Cr在電位0.5 V之鈍態電流密度I0.5 (5.50 μA/cm2)低於c.p. Ti (47.08 μA/cm2),顯示Ti-30Cr合金在含氟量高的人工唾液中具有較好的耐蝕性質。並且ESCA分析結果顯示,所有Ti-Cr合金在含氟人工唾液中表面會生成含Cr的氧化物 (Cr2O3),故能提高耐蝕性質。MTT assay結果顯示,添加Cr元素對於MG-63類骨母細胞無不良影響,細胞培養至第7天時,細胞在c. p. Ti和Ti-Cr合金表面生長狀況無明顯差異。Ti-Zr合金方面,在不含氟人工唾液中Ti-Zr合金與c.p. Ti的 Ecorr和Icorr有顯著差異 (p>0.01),其中Ti-40Zr之Ecorr值 (-1.05 V)高於c.p. Ti (-1.11 V),與Icorr值 (0.27 μA/cm2) 低於c.p. Ti (0.69 μA/cm2),顯示出在不含氟人工唾液中Ti-Zr合金有較好的耐蝕性,在含0.5 wt% NaF人工唾液中Ti-40Zr之Ecorr值與c.p. Ti 沒有顯著差異,但Icorr值 (911.33 μA/cm2)高於c.p. Ti (62.51 μA/cm2),Ti-40Zr在電位0.5 V之鈍態電流密度I0.5 (973.34 μA/cm2)高於c. p. Ti (47.08 μA/cm2),顯示出在含氟人工唾液中Ti-Zr合金耐蝕性較差。經ESCA分析結果顯示,於Ti-Zr合金表面所產生的ZrO2並不能提升Ti-Zr合金於含氟人工唾液中的耐蝕性質。MTT assay結果顯示, Ti-Zr合金表面培養MG-63細胞,於第7天時細胞數量無明顯差異,表示細胞在Ti-Zr合金表面有良好的生長情形。
Titanium and its alloys are widely used in the medical field. In particular, β-titanium has been the topic of much research due to its low rigidity and a Young’s modulus which is close to that of cortical bone. This research aimed to evaluate corrosion behavior and biocompatibility of Ti-Cr and Ti-Zr alloys. Firstly, specimens were tested for corrosion in a standard artificial saliva solution and an artificial saliva solution containing NaF. The surfaces of the specimens were analyzed by SEM and ESCA. In order to conduct the biocompatibility test, the MG-63 was cultured 1, 4 and 7 days. The cell growth morphology was observed by SEM. In addition, MTT assay was used to estimate biocompatibility. The results of corrosion test showed that the corrosion potential (Ecorr) and corrosion current density (Icorr) of different specimens were not significantly different (p<0.01) in the standard artificial saliva. In contrast, in the artificial saliva containing 0.5 wt% NaF, Ti-30Cr showed higher Ecorr values and lower Icorr and passive current density values than all other alloys, which indicates generally superior corrosion resistance. In general, the Ti-Cr alloys showed good corrosion resistance. In contrast, none of the Ti-Zr alloys showed adequate corrosion resistance in artificial saliva containing NaF. Further, ESCA analysis showed that all specimens formed surface oxide films, but only in trh case of the Ti-Cr specimens did this appear to have a positive effect. On the other hand, MG-63 cell growth on all specimens showed good biocompatibility.
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