慢性腎臟病之血管鈣化與治療

慢性腎臟病的血管鈣化與死亡率有相當大的關係。血管鈣化不僅是血鈣與血磷的調控異常所致，並且是一個活性多變過程。血管鈣化機制由多重因子來調控，包括：不正常血鈣和血磷、全身性發炎反應、副甲狀腺機能亢進。次發性副甲狀腺機能亢進與骨骼置換率低下時，血液的鈣和磷均會升高而增加血管鈣化的機率。治療血管鈣化有相當多方式，取決於病患本身骨骼置換率的狀態，治療的主要目標是維持正常的骨骼轉換率以及減少血管鈣化發生。

關鍵字

慢性腎臟病；血管鈣化；高血磷；動脈中層鈣化；磷結合劑

並列摘要

In chronic kidney disease pateints, the severity of vascular calcification and the mortality rate are closed related. The causes of vascular calcification are not only the imbalance of serum calcium and phosphate but a variously dynamic process. The mechanisms of vascular calcification are controlled by mutiple factors include abnormal serum calcium and phosphate, system inflammation responses, hyperparathyroidism. Secondary hyperparathyroidisms lead to low bone turnover rate, which results in high levels of serum calcium and phosphate to increase vascular calcification possibility. Among a lot of strategies to treat vascular calcification, the key is the bone turnover rate of patient. Therefore, the main goal is maintaining a regular bone turnover rate to prevent the vascular calcification.

並列關鍵字

chronic kidney disease ； vascular calcification ； hyperphosphatemia ； medial arterial calcification ； phosphate binders

國際替代計量

慢性腎臟病之血管鈣化與治療

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