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Clinical Study of Oral Trazodone in the Treatment of 25 Impotent Patients

使用Trazodone治療陽萎病人的臨床試驗

摘要


Trazodone這個口服抗憂鬱藥,曾經被報告說能延長正常男人的勃起時間、以及使陽萎的病人獲得改善。我們使用Trazodone一天三次,每次五十毫克來治療二十五位陽萎病人。有四位病人在第一週內停止用藥,其中三位是因為有嚴重的嗜睡現象,一位是因為小便困難。在剩下的二十一位病人中,四位被診斷為心理因性陽萎,十七位為器官性陽萎。經過四周的用藥,利用問卷來評估效果。 對於用藥整體的有效率是52.4%。在器官性陽萎的病人裡面,治療效果在不同的年齡群中並沒有顯著的差異。然而對於那些陽萎時間小於等於十八個月內的病人群,治療的有效率(75.0%),卻遠大於陽萎時間超過十八個月的病人群(22.2%,P值等於0.0296%)。在這些病人中性慾方面則沒有明顯的改變。 Trazodone的副作狦包括了高頻率的嗜睡(84%)、虛弱(48%)、口乾(40%)以及視力模糊(24%),並且有兩位病人出現腎臟功能變差的現象。 總結來說,Trazodone對於一部份陽萎病人的治療是有效的,特別是對於陽萎時間在十八個月以內的病人,治療效果較好。因此陽萎愈早被診斷,治療成功的機率愈大。Trazodone的副作用需要小心的監測。我們仍需要一個更大型的雙盲試驗(Double-blind test)來確認它的效果,以及決定它的最適劑量。

關鍵字

陽萎 勃起。

並列摘要


Trazodone is an oral antidepressant that has been reported to prolong erections of potent men and to improve erections of impotent patients. We administered 50 mg trazodone three times a day to twenty-five impotent patients. Four patients discontinued the medication within the first week due to severe drowsiness in three patients and difficulty in urination in one. Of the re-maining 21 patients, four were diagnosed with psychogenic impotence and 17 with organic im-potence. After four weeks of medication, the results were evaluated by questionnaires. The overall response rate to the mediction was 52.4%. Among the patients with organic impotence, there was no significant difference in response to the medication between the differ-ent age groups. However, the overall response rate to the medicaton was much higher in the patients who were impotent for 18 months or less (75.0%) than in the patients who suffered from impotency more than 18 months (22.2%, p=0.0296). There was no obvious change n libido in thse patients. Side effects included a high percentage of drowsiness (84%), weakness (48%), dry mouth (40%) and blurred vision (24%). Impaired renal function also occurred in two patients. In conclusion, trazodone is effective for some mpotent patients. It was more effective in treating patients who suffered from impotency for 18 months or less. Thus, the earlier impotence is diagnosed the better chance there is for successful treatment. Te side effects should be moni-tored carefully. A large double-blind series is needed to confirm the results and determine the optimal dose of trazodone. (J Urol R.O.C., 9:7-11,1998)

並列關鍵字

trazodone impotence erection.

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