Innovation supports the knowledge as the major input in the production process. Since the knowledge, in a certain degree, exhibits some properties of public goods such as nonexclusion and nonrivalry such that firms might operate in regions of falling AC where the production technology exhibits increasing returns to scale. This kind of production style inevitably encourages firms to expand their economic scales via mergers. This article uses the propositions of the endogenous growth models to investigate the antitrust policy in a knowledge-based economy. We argue that government should loosen their regulations to facilitate the mergers; this might encourage local firms to evolve into multi-national enterprises. Besides, the government should foster greater understanding of emerging global issues and promote the international cooperation necessary to address them.