In recent years, highway slope failure has been widely studied by geotechnical engineers. However, Conventional investigations for determining slope failure have focused on the linear relationships among many factors, such as slope angle, slope height, material, construction, rainfall, earthquake and so on. In fact, this problem is still a complex nonlinear relationship. This paper presents an application of an artificial neural network for assessing slope failure using these factors. On site slope failure data for Taiwan’s Highway 20 (South-Cross Highway) and the Highway 18 (A-Li-San Highway) were used to test the performance of the artificial neural network model. The results indicate that the artificial neural network can efficiently estimate slope failure potential using the major factors.