Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a relatively uncommon but potentially serious complication of treatment with nitrogen-containing bisphosphonates. This is a case of BRONJ in maxilla. After six months treatment, including sustained change dressing and twice surgical debridement, the refractory osteonecrosis was completely recovered. The wound had healed well, but inevitably an oroantral communication was happened. This problem results in difficulty in swallowing, and speech function. The rehabilitation of patients with the acquired defect of the maxilla is a challenge in terms of re-establishing oroantral separation. The goal is achieved by prosthetic rehabilitation with an obturator prosthesis. Not only the oroantral separation but also the acceptable occlusion were obtained. Life quality of the patient has been improved vastly after a series of wound treatment and oral reconstruction.