The biodegradable membrane we developed today is unlike the purified collagen membranes in the past. The biomimetic membrane of new generation uses enzyme to remove the cells and antigens in living tissue and keep the active proteins supporting the healing process. Besides, this kind of biomimetic membrane, which is with the natural intact extracellular matrix, normally has better mechanical strength than traditional collagen membrane. This article attempt to evaluate the Horien biomimetic membranes which may have potential for guided tissue regeneration.