- 期刊
Comparison of Immunogenicity of Simultaneous and Simultaneous and Nonsimultaneous Vaccination with MMR and JE Vaccine among 15-month-old Children
麻疹、德國麻疹、腮腺炎混合疫苗和日本腦炎疫苗分開間隔接種或同時接種之血清抗體反應評估
摘要
本研究目的在比較日本腦炎與麻疹、德國麻疹、腮腺炎三合一疫苗同時接種於人體不同部位及此兩種疫苗間隔6週接種的血清抗體反應，並記錄接種後幼兒的不良反應。 自1994年3月至7月，高醫小兒科收集附設醫院門診、高雄市三民與鼓山衛生所擬接受預防接種之15個月大200幼兒個，將其分成兩組。第一組爲「分開接種組」，令其於15個月大時接種三合一疫苗並測定麻疹、德國麻疹、腮腺炎與日本腦炎的血清基凖值，再於6週後施打第一劑日本腦炎疫苗，再2週後施打第二劑日本腦炎疫苗並抽血檢查麻疹，德國麻疹，腮腺炎抗體力價上升情；而再隔6週後則抽血檢查日本腦炎抗體力價上升情形。第二組爲「同時接種組」，令其於15個月大時同時於不同部位接種此兩種疫苗並抽血測定4種病毒的血清抗體基凖值，再2週後施打第二劑日本腦炎疫苗，而再隔6週後則抽血檢查此4種病毒抗體力價上升情形。 結果「分開間隔接種組」共完成61個，而「同時接種組」共完成57個有效安例。 「分開間隔接種組」接種後的麻疹、德國麻疹、腮腺炎與日本腦炎抗體加力價對數化平均值，分別爲4.51，5.93，4.07與1.99；而其血清陽轉率則分別爲100% (61/61), 96.72% (59/61)，77.05% (47/61), 59.02% (36/61)。 「同時接種組」的同項疫苗抗體的增加力價對數化平均值分別爲4.35，5.37，4.44與1.93；而其血清陽轉率則分別爲98.25% (56/57), 77.19% (44/57), 98.25% (56/57) ，5 7.89% (33/57)。將兩組的同種疫苗配對做比較，發現無論在抗體的平均增加力價或血清陽轉率，皆無統計上之差異。因此，結論認爲此兩種疫苗同時接種或分開間隔接種，其産生抗體的能力是相當的。
並列摘要
To evaluate the immunogenicity of measles-mumps-rubella (MMR) vaccination with Japanese encephalitis (JE) vaccine nonsimultaneously and simultaneously, 145 babies, aged 15 months were enrolled into two groups. Group A received MMR and JE vaccines nonsimultaneously at an interval of 6 weeks; group B received the vaccinations simultaneously. Antibody titers of MMR and JE were detected before and 8 weeks after vaccination. A total of 118 babies (61 in group A; 57 in group B) completed the study. In group A, mean increments of logarithmic geometric mean titers (GMTs) of MMR and JE were 4.51, 5.93, 4.07 and 1.99; seroresponse rates were 100% (61/61), 77.05% (47/61), 96.72% (59/61) and 59.02% (36/61) respectively. In group B, mean increments of logarithmic GMTs of MMR and JE were 4.35, 5.37, 4.44 and 1.93; seroresponse rates were 98.25% (56/57), 77.19% (44/57), 98.25% (56/57) and 5 7.89% (33/57) respectively. There were no significant differences between these two groups. These results suggest that simultaneous and nonsimultaneous vaccination with MMR and JE vaccines were similar in immunogenicity.
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