- 期刊
Expression of Thyroid Hormone Receptors in Intracranial Meningiomas
甲狀腺激素受器在人類腦膜瘤之表現
摘要
甲狀腺激素在人體器官功能上扮演一個重要的角色。而甲狀腺激素在體內的作用，則是經由甲狀腺激素受器來調控。本研究藉由手術取得之腦膜瘤組織，以反轉錄/聚合酵素連鎖反應的方法，檢測人類腦膜瘤細胞中，甲狀腺激素受器不同的表現方式，來推測腦膜瘤的臨床表現與預後。本研究以在本院手術取得的25個腦膜瘤病例之腫瘤細胞為研究對象，發現不同類型的腦膜瘤各有不同的甲狀腺激素受器表現方式：甲狀腺激素受器α1(在9個病例中表現出來)；甲狀腺激素受器α2(有14個病例表現)；α1及α2均有表現(5個病例)；而甲狀腺激素受器β1在9個復發性或侵襲性的腦膜瘤病例均有明顯的表現。由上述結果可得知，甲狀腺激素受器β1與腦膜瘤的預後有關，可作為腫瘤復發或癌化的指標。
並列摘要
Thyroid hormone has a unique function in human organs. Many of its effects occur at the level of gene expression and are mediated by thyroid hormone receptors (TRs). We investigated the relationship between TRs and the prognosis of meningiomas. We investigated TR expression in human intracranial meningiomas using reverse transcription-polymerase chain reaction. Specimens of 25 tumors were obtained by craniotomy from I various intracranial meningiomas. We found that the expression of TRs was receptor subtype- and cell type-dependent. Human TRαl (hTRα1) was expressed in nine cases, hTRα2 was expressed in 14 cases, and both hTRαl and hTRα2 were expressed in five cases; hTRβ1 was expressed in nine cases of recurrent or malignant tumors. The expression of hTRβ1 may be an indicator of recurrent or malignant meningiomas.
延伸閱讀
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