Cerebral Radionecrosis in Patients with Nasopharyngeal Carcinoma

本研究報告7名鼻咽癌病患接受放射線治療後產生放射線性壞死。我們重新審視病歷並探討其與顱外惡性腫瘤之腦部放射線壞死的相關性。放射劑量從70到135格雷，潛伏期自6個月到39個月。2名病患在追蹤期死於鼻咽癌相關併發症。鼻咽癌之腦部放射性壞死的粗發生率在我們的報告是0.93%。經由接受皮質類固醇治療有或沒有接受手術均獲得症狀的改善。回顧文獻，一共有306位顱外惡性腫瘤病患有放射線性壞死。鼻咽是最常見的原發腫瘤部位，接下來依序是頭皮以及鼻竇。3年整體存活率經Kaplan-Meier法計算是68.57%。鼻咽癌放射性壞死病患必須要和腫瘤複發作鑑別診斷，以給予適當的治療。

關鍵字

放射線性壞死；鼻咽癌

並列摘要

This study involved seven patients with cerebral radionecrosis following radiation therapy for nasopharyngeal carcinoma (NPC). Their charts were reviewed and the relationship of extracranial malignancies to cerebral radionecrosis was investigated. The radiation dose ranged from 70 to 135 Gy, and the latency was from 6 to 39 months. Two of seven patients died of NPC-related complications during follow-up. The crude incidence of cerebral radionecrosis in patients with NPC was 0.93% in our series. Improvement of symptoms could be achieved by corticosteroid therapy, with or without surgery. In a review of the literature, there were 306 cases of cerebral radionecrosis in extracranial malignancies. The nasopharynx is the most common primary site in cerebral radionecrosis of extracranial malignancies, followed by the scalp and sinonasal tract. The 3-year overall survival rate in our series was 68.57%, as provided by the Kaplan-Meier product limited method. Cerebral radionecrosis in NPC patients should be differentiated from tumor recurrence, in order to apply the appropriate treatment.

並列關鍵字

radionecrosis ； nasopharyngeal carcinoma

國際替代計量

Cerebral Radionecrosis in Patients with Nasopharyngeal Carcinoma

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