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Subtotal esophagectomy and reconstruction with colonic interposition grafting is the usual surgical treatment for benign esophageal stricture and malignant esophageal cancer. While short-term complications are frequently reported, long-term complications are rare. Herein, we report a 57-year-old male, with a previous caustic injury to the esophagus who underwent subtotal esophagectomy and right colon grafting at age 18. He underwent left hemicolectomy for obstructive colon cancer at the splenic flexure at age 55, followed by resection of the interposed colon graft due to adenocarcinoma at age 57.

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