The effect of daily consumption of the small fish Amblypharyngodon mola or added vitamin A on iron status: a randomised controlled trial among Bangladeshi children with marginal vitamin A status

日常小鱼（翻车鱼）摄入或添加维生素A对儿童铁状况的影响：一项在孟加拉国临界维生素A状态儿童中的随机对照试验

Anna B Andersen ； Lise KH Schmidt ； Daniel Faurholt-Jepsen ； Nanna Roos ； Henrik Friis ； Katja Kongsbak ； Mohammed A Wahed ； Shakuntala Haraksingh Thilsted

《Asia Pacific Journal of Clinical Nutrition》 25卷3期 (2016/09) Pp. 464-471

https://doi.org/10.6133/apjcn.092015.11

摘要

背景和目的：翻车鱼是一种营养丰富在孟加拉国池塘和稻田中发现的小鱼。该干预研究的目的是评估翻车鱼摄入对临界维生素A状态儿童铁含量的影响。方法和研究设计：196名年龄在3-7岁之间、临界维生素A状态的孟加拉国儿童被随机分配到3个干预组中的一组，给予不同的鱼咖喱：鱼咖喱（实验组）、瑞（鲮）添加维生素A棕榈酸酯咖喱（阳性对照组）；或瑞咖喱（阴性对照组）。干预膳食为每周6天共9周。实验组和阳性对照组给予相同数量的视黄醇活性当量。翻车鱼铁含量为瑞咖喱铁含量的4倍。分别在基线和研究终点测定血红蛋白、铁蛋白、血清转铁蛋白受体和C-反应蛋白含量。结果：与阳性对照组相比，鱼咖喱实验组血清转铁蛋白受体的浓度低至0.73 mg/L(95% CI 0.17，1.28，p=0.01)，而两组间铁蛋白和血红蛋白含量无统计学意义。结论：翻车鱼，而不是瑞咖喱的摄入对临界维生素A状态的儿童铁含量有影响，可作为血清转铁蛋白受体水平下降的标志。

關鍵字

铁 ； 维生素A ； 视黄醇 ； 营养丰富的小鱼 ； 孟加拉国

並列摘要

Background and Objectives: Mola (Amblypharyngodon mola) is a nutrient-rich, small fish found in ponds and rice fields in Bangladesh. The aim of the present intervention was to assess the effect of mola consumption on iron status in children with marginal vitamin A status. Methods and Study Design: Bangladeshi children (n=196), aged 3-7 years, with marginal vitamin A status were randomly allocated to one of three intervention groups served different fish curries: mola curry (experimental group); rui (Labeo rohita) curry with added retinyl palmitate (positive control group); or rui curry (negative control group). The intervention meals were served 6 days/week for 9 weeks. The experimental and positive control meals were designed to contain similar amounts of retinol activity equivalents per portion. The mola curry contained four times more iron compared to the rui curries due to different iron content in the two fish species. Haemoglobin, ferritin, serum transferrin receptor and Creactive protein were measured at screening and endpoint. Results: In the experimental group receiving mola, serum transferrin receptor concentration declined 0.73 mg/L (95% CI 0.17, 1.28, p=0.01) compared to the positive control group, while there were no differences between groups in ferritin or haemoglobin. Conclusions: Consumption of mola instead of rui has potentially an effect on iron status in children with marginal vitamin A status, seen as a decrease in serum transferrin receptor concentration.

並列關鍵字

iron status ； vitamin A ； serum retinol ； small nutrient-rich fish ； Bangladesh