- 期刊
Dietary fiber intake is associated with chronic kidney disease (CKD) progression and cardiovascular risk, but not protein nutritional status, in adults with CKD
摘要
Background and Objectives: Evidence suggests that dietary fiber benefits patients with chronic kidney disease (CKD); however, this conclusion requires further validation. In this study, we examined the effects of dietary fiber on kidney function, inflammation, indoxyl sulfate, nutritional status, and cardiovascular risk in patients with advanced CKD. Methods and Study Design: We performed linear regressions to assess the association between dietary fiber intake and CKD parameters. The aforementioned parameters were compared over an 18-month follow- up period. Kaplan–Meier analysis was used to investigate the association between fiber intake and Cardiac vascular disease (CVD). Results: In total, 157 patients were included in this study. Dietary fiber and inflammatory indices were associated (interleukin [IL]-6: β=−0.024, p=0.035). The differential estimated glomerular filtration rate (ΔeGFR) as well as levels of C-reactive protein, IL-6, indoxyl sulfate, and serum cholesterol in the higher fiber intake (≥25 g/day) group were lower than those in the lower fiber intake (＜25 g/day) group (p＜0.05). Differences in IL-6 and indoxyl sulfate levels were more significant in patients in the higher protein intake group (p＜0.05). Dietary fiber intake may be a protective factor associated with CVD (hazard ratio=0.537 and 0.305– 0.947). The protein nutritional status was not different between the two groups (p＞0.05). Conclusions: Our results suggest that increasing fiber intake can retard the decrease in the eGFR; can reduce the levels of proinflammatory factors, indoxyl sulfate, and serum cholesterol; and is negatively associated with cardiovascular risk, but does not disrupt the nutritional status of patients with CKD.
延伸閱讀
- 羅培倫、章慧如、李佩銜、陳梅恩、蕭仕敏、王淑麗、黃孟娟（2019）。The Effect of Nutritional Counseling on the Changes of Nutritional Intake and Biochemical Indicators in Outpatients With Chronic Kidney Disease。臺灣膳食營養學雜誌，11(2)，27-36。https://doi.org/10.6709/TJD.201912_11(2).0003
- 吳紅蓮、吳莉葳（2022）。The Importance of Dietary Fiber for Patients With Chronic Kidney Disease。腎臟與透析，34(2)，85-90。https://doi.org/10.6340/KD.202206_34(2).0007
- Sio, Y. C., Lin, C. Y., Zeng, G. Q., Liao, C. T., Chen, J. Y., Kao, C. C., Shih, C. C., Wu, M. S., Lu, H. Y., & Lin, Y. C. (2023). Effects of Oral Ferric Citrate or Intravenous Iron Supplement on Biomarkers of Chronic Kidney Disease-Mineral Bone Disorder and Cardiovascular Events in Patients Undergoing Long-Term Hemodialysis. Acta Nephrologica, 37(1), 34-48. https://doi.org/10.6221/AN.202303_37(1).0004
- Wu, N., Yu, X., Greene, M., & Oderda, G. (2014). Evaluation of the Prevalence of Chronic Kidney Disease and Rates of Oral Antidiabetic Prescribing in Accordance with Guidelines and Manufacturer Recommendations in Type 2 Diabetic Patients within a Long-Term Care Setting. International Journal of Nephrology, (2014), 31-40. https://doi.org/10.1155/2014/151706
- 廖述寬、田亞中、張智翔（2022）。Clinical Practice Guideline for Protein Intake in Chronic Kidney Disease。腎臟與透析，34(3)，132-136。https://doi.org/10.6340/KD.202209_34(3).0006