Coexistent Systemic Amyloidosis, Multiple Myeloma, and Refractory Anemia with Ringed Sideroblasts in a Previously Untreated Patient

Sangeeta Mehendale ； Pritesh Patel ； Valerie Lindgren ； Damiano Rondelli ； Sujata Gaitonde

《International Journal of Case Reports and Images (IJCRI)》 2卷2期 (2011/02) Pp. 1-4

https://doi.org/10.5348/ijcri-2011-02-17-CR-1

並列摘要

Introduction: We report the first case of coexistent systemic amyloidosis, plasma cell myeloma (MM), and myelodysplastic syndrome (refractory anemia with ringed sideroblasts:MDS-RARS). Case Report: Our patient was diagnosed with amyloidosis of the liver, stomach and tongue following which a bone marrow biopsy was performed. Review of the bone marrow biopsy revealed the presence of two distinct entities that have rarely been detected together; MM and MDS-RARS. There was no history of prior radiation or chemotherapy. Conclusion: Concurrent de novo disease processes involving both myeloid and lymphoid cell lines may not be as rare as they seem. Cytopenias in patients with MM must trigger a thorough investigation for an associated concurrent myeloid disorder. Presence of concurrent MDS would influence the choice of therapy and these patients need to be watched closely for progression of the myeloid disorder.

並列關鍵字

Myeloma ； Myelodysplastic syndrome ； De novo