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Postpartum Fatal Fulminant Hepatic Failure Presenting with Persistent Hypoglycemia Due to Acute Fatty Liver of Pregnancy
摘要
Acute fatty liver of pregnancy (AFLP) is a sudden and devastating illness which occurs mostly around the 36^(th) week of gestation in pregnant females. It is characterized by microvesicular fatty infiltration of the liver which eventually results in encephalopathy and hepatic failure. It carries significant perinatal and maternal mortality and requires early diagnosis and intervention to prevent maternal and fetal death. The foremost cause of AFLP is thought to be due to a mitochondrial dysfunction in the oxidation of fatty acids leading to their continuous accumulation in the hepatocytes. Early diagnosis is extremely important and the only definitive therapy is delivery. Here, we present the case of a 28-year-old pregnant female presenting with abdominal pain, vomiting, and jaundice who was diagnosed with AFLP and gradually worsened postpartum. Due to persistent hypoglycemia and rapidly developing fulminant hepatic failure, the patient expired 5 days after admission.
延伸閱讀
- Shi, M. Y., Hsieh, P. J., Kuo, Y. S., Huang, S. H., Wang, Y. C., & Sun, C. M. (2015). An Atypical Hepatic Hemangioma Mimicking Liver Metastasis. 核子醫學暨分子影像雜誌, 28(2), 91-94. https://doi.org/10.6332/ANMMI.2802.006
- Hu, C. T., & Lin, H. H. (2004). Multifocal Inflammatory Pseudotumors in a Patient with Cirrhotic Liver and Very High Alpha-Fetoprotein: Report of a Case. 臺灣消化醫學雜誌, 21(2), 155-162. https://doi.org/10.6557/GJT.200406_21(2).0006
- Tang, H. H., Tsai, Y. C., Kang, C. Y., Chung, M. T., Loo, T. C., & Huang, K. F. (2007). Atypical Ovarian Hyperstimulation Syndrome with Isolated Pleural Effusion but Without Ascites or Hemoconcentration. Taiwanese Journal of Obstetrics & Gynecology, 46(2), 180-182. https://doi.org/10.29787/TJOG.200706.0015
- Lin, P. H., Lo, Y. C., Chiang, F. T., Wang, J. L., Jeng, Y. M., Fang, C. T., & Chang, S. C. (2008). Acute Q Fever Presenting as Fever of Unknown Origin with Rapidly Progressive Hepatic Failure in a Patient with Alcoholism. Journal of the Formosan Medical Association, 107(11), 896-901. https://www.airitilibrary.com/Article/Detail?DocID=09296646-200811-107-11-896-901-a
- BILLING, J. S., & JAMIESON, N. V. (1997). Hepatic Arterioportal Fistula: A Curable Cause of Portal Hypertension in Infancy. HPB Surgery, 1997(), 311-314. https://doi.org/10.1155/1997/58026