Respiratory syncytial virus (RSV) is a common pathogen that causes respiratory tract infection and has been found to co‑infect with other bacteria. Although the virus can cause morbidity and mortality in the elderly, RSV‑bacteria co‑infection had rarely been reported. In this paper, we reported the case of an elderly woman with RSV and Streptococcus pneumoniae co‑infection in a familial cluster during the COVID‑19 pandemic era. The patient was treated appropriately and showed complete recovery.