米麩能改善糖尿病老鼠餐後血糖反應

Dietary Rice Bran Improves the Glycemic Response in Rats with Streptozotocin-induced Diabetes

賴明宏(MIng-Hoang Lai) ； 林育如(Yu-Ju Lin) ； 洪美鈴(Mei-Ling Hung) ； 鄭心嫻(Hsing-Hsien Cheng)

《中華民國營養學會雜誌》 26卷3期 (2001/09) Pp. 159-170

https://doi.org/10.6691/JCNS.200109_26(3).0002

摘要

本研究的主要目的在探討富含膳食纖維的米麩飲食對streptozotocin(STZ)誘導的糖尿病老鼠其血糖；血脂及對股病變之影響。將40隻雄性Wistar老鼠（平均300克）隨機分成兩組，一半利用STZ誘導成糖尿病老鼠。再將STZ誘導的糖尿病老鼠及無糖尿病老鼠隨機分成兩組，分別餵與AIN 76正常老鼠飼料配方飲食及米麩飲食（20 g/100 g diet）。餵食四週後，不論是餵AIN 76飲食或米麩飲食之糖尿病鼠皆有高血糖，但米麩飲食組明顯降低其血中果糖胺值（和其基準值比），且和AIN 76飲食組比有較低的葡萄糖耐量試驗面積。AIN 76飲食之糖尿病鼠組血中總膽固醇濃度明顯升高（和其基準值比），但米麩組並沒有變化。糖尿病鼠在AIN 76飲食組及米麩飲食組皆有明顯高肌酸酐值及蛋白尿。依數據顯示：米麩飲食能有效降低血中果糖胺值及減緩葡萄糖耐量試驗之血糖反應面積，但並未觀察到有延緩糖尿病腎病變之情形。

關鍵字

米麩 ； 糖尿病鼠 ； 血糖反應

並列摘要

A 2 x 2 factorial experimental design was employed to evaluate the effect of a fiber-rich rice bran diet on blood glucose, lipid and diabetic nephropathy in streptozotocin (STZ)-induced diabetic rats. Forty ale adult Wistar rats were randomly divided into four groups, two of which were injected with nicotinamide and STZ to induce diabetes. Both normal and STZ-diabetic rats were fed AIN-76 diets and rice bran diets (20 g/100 g diet). After 4 weeks of feeding, STZ-diabetic rats both with and without rice bran were significantly (p ＜ 0. 05) hyperglycemic. Blood fructosamine was ameliorated in rice bran diet-fed STZ-diabetic rats, compared with the baseline. STZ-diabetic rats fed a rice bran diet had a significantly lower blood glucose response than those fed the diet without rice bran. Blood totota1 cholesterol was higher than baseline in AIN-76 diet-fed STZ-diabetic rats, but it had not changed in rice bran diet-fed STZ-diabetic rats. In STZ-diabetic rats, blood creatinine and proteinuria were significantly higher than in nondiabetic rats. These results suggest that a rice bran diet is effective in lowering blood fructosamine and improving the glucose response, but it cannot retard the development of diabetic nephropathy in STZ-diabetic rats.

並列關鍵字

rice bran ； diabetic rats ； glycemic response