- 期刊
- OpenAccess
Short-Term Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Emergency Department Visits and Hospitalizations Among Patients with Type 2 Diabetes: A Real-World Evidence
摘要
BACKGROUND: The long-term benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on heart failure in patients with type 2 diabetes mellitus (T2DM) have been well documented. However, the short-term effects (around 1 year after using SGLT2i) on the clinical outcomes of patients with T2DM remain unknown. This retrospective cohort study investigated the short-term effects of SGLT2i on clinical outcomes in patients with T2DM. METHODS: Participants are the patients using metformin that had received diagnoses of diabetes between January and December 2016, and they were selected from a nationwide database of Taiwan. Patients using SGLT2i were grouped into the case group (n = 768) and patients not using SGLT2i were grouped into the control group (n = 2,304) at a matching ratio of 1:3 with a mean follow-up time of 1.7 ± 0.3 years. RESULTS: After multivariable analysis, users of SGLT2i had a significantly higher risk of emergency department (ED) visits and hospitalizations compared with SGLT2i nonusers. However, only the negative effects of SGLT2i on ED visits remained significant after the inclusion of the data from the 3-month delay analysis (hazards ratio, 1.29; 95% confidence interval, 1.09-1.53). Therefore, patients with T2DM who received therapy with SGLT2i were associated with a higher risk of ED visits over a short-term observation period. CONCLUSION: Patients with T2DM who received therapy with SGLT2i exhibit an association with a higher risk for ED visits in a short-term observation period.
延伸閱讀
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