- 期刊
- OpenAccess
Proton-Pump Inhibitor is a Risk Factor for Hospital-Acquired Acute Kidney Injury in Elderly: A Case-Control Study
摘要
BACKGROUND: Hospital-acquired acute kidney injury (HA-AKI) is a common clinical problem in hospitalized patients. Its incidence is high in older patients and it carries a worse prognosis. This study aims to evaluate the risk factors of HA-AKI in elderly patients. METHODS: This retrospective case-control study was conducted from January 2018 to December 2019 in the Ditmanson Foundation Chia-Yi Christian Hospital. A total of 447 admissions with HA-AKI among elderly (≥ 75 years of age) patients were obtained. HA-AKI was defined and staged according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria. Propensity score matching was used to compare HA-AKI and non-AKI admissions for the risk factors of HA-AKI. RESULTS: HA-AKI admissions had an average of about 7 days (17.60 ± 11.94 vs. 10.94 ± 7.28, P ＜ 0.001) longer length of hospital stay, with 4.4 times (69 vs. 16, P ＜ 0.001) more admissions lasting more than 30 days, and 15 times (170 vs. 11, P ＜ 0.001) higher in-hospital mortality rates, in comparison with non-AKI admissions. Respiratory failure, pulmonary edema, acute coronary syndrome/acute myocardial infarction, sepsis, malignancy, gout, as well as prescribed diuretics and proton-pump inhibitors (PPIs) were risk factors in HA-AKI (P ＜ 0.05). CONCLUSION: HA-AKI in elderly patients is associated with increased in-hospital morbidity and mortality. Prescription of PPIs may be one of the novel risk factors for HA-AKI. Our data contribute to the potential risks of the clinical use of PPIs in elderly patients with HA-AKI.
延伸閱讀
- 蔡佳勳（2017）。Proton-Pump Inhibitor Use Is Associated With fracture in diabetic patients〔碩士論文，中山醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0003-2908201715270600
- Ho, W. Y., Hsieh, Y. J., Chen, K. H., Jenq, C. C., Hsu, H. H., Tian, Y. C., Yang, C. W., Yen, C. C., & Yang, H. Y. (2022). Clinical Characteristics Predicting Acute Kidney Injury Among Patients With Urinary Tract Infection. Acta Nephrologica, 36(2), 90-100. https://doi.org/10.6221/AN.202206_36(2).0005
- 黃煥智、吳建誼、莊昀璇、龔蘭芳、郭美娟、方姿蓉（2022）。Investigation of Clinical Factors for Receiving Palliative Care among Elderly Patients with Advanced Kidney Disease。台灣老年醫學暨老年學會雜誌，17(3)，208-220。https://doi.org/10.29461/TGGa.202208_17(3).0003
- Sabaz, M. S., & Hergünsel, G. O. (2022). The Effect of Acute Kidney Injury on Mortality in Geriatric Patients Followed Up in the Intensive Care Unit. International Journal of Gerontology, 16(2), 133-138. https://doi.org/10.6890/IJGE.202204_16(2).0011
- Durand, C., Willett, K. C., & Desilets, A. R. (2012). Proton Pump Inhibitor use in Hospitalized Patients: Is Overutilization Becoming a Problem?. Clinical Medicine Insights: Gastroenterology, 2012(), 65-76. https://doi.org/10.4137/CGast.S9588