- 期刊
- OpenAccess
Beneficial Effects of Combined PPARδ and EPO Treatment on Rats with Chronic Kidney Disease
摘要
BACKGROUND: Hyporesponsiveness to erythropoietin (EPO) is a common problem for patients with chronic kidney disease (CKD). More effective treatments to improve EPO response are needed. METHODS: We used in vitro K562 cell and in vivo 5/6 nephrectomy rat CKD models to explore the relationship between EPO and peroxisome proliferator-activated receptor δ (PPARδ) agonists, and use quantitative PCR to confirm the molecular level. RESULTS: Interleukin-1 (IL-1) was shown to decrease EPO receptor expression in K562 cells. The IL-1-induced inhibition could be reversed by PPARδ agonist. PPARδ agonists significantly decreased blood IL-1, interleukin-6 (IL-6), tumor necrosis factor α, and C-reactive protein levels, inhibited kidney expression of two apoptosis-promoting proteins, caspase 3 and BAX, and enhanced the hematopoietic effect of EPO in rats with 5/6 nephrectomy. (CKD). CONCLUSION: The anti-inflammatory and anti-apoptotsic effects of PPARδ agonists may help to improve EPO hyporesponsiveness in CKD patients.
延伸閱讀
- Chen, C. F., Chen, L. W., & Chien, C. T. (1995). Effects of Aprotinin on Renal Function in Chronic Hypoxic Rats. The Chinese Journal of Physiology, 38(1), 23-26. https://www.airitilibrary.com/Article/Detail?DocID=03044920-199503-38-1-23-26-a
- Guo, Y., Zhang, M., Ye, T., Qian, K., Liang, W., Zuo, X., & Yao, Y. (2022). Non-protein energy supplement for malnutrition treatment in patients with chronic kidney disease. Asia Pacific Journal of Clinical Nutrition, 31(3), 504-511. https://doi.org/10.6133/apjcn.202209_31(3).0017
- Chen, S. M., Kuo, C. D., Liao, J. F., & Ho, L. T. (2005). Effects of Parathyroid Hormone on Plasma Zinc Concentration in Rat with Chronic Renal Failure. The Chinese Journal of Physiology, 48(3), 121-128. https://www.airitilibrary.com/Article/Detail?DocID=03044920-200509-48-3-121-128-a
- Yang, C. P., Liu, H. J., Chou, L. S., & Lin, M. T. (1992). Effects of Intra-Raphe Injection of Amino Acids on Cardiovascular Function in Rats. The Chinese Journal of Physiology, 35(2), 143-149. https://www.airitilibrary.com/Article/Detail?DocID=03044920-199206-35-2-143-149-a
- 黃文德、朱柏齡、許育瑞（2014）。Recent Advances in the Use of Oral Phosphate Binders in Patients with Chronic Kidney Disease。內科學誌，25(3)，184-194。https://doi.org/10.6314/JIMT.2014.25(3).08