Difference in the Prevalence of CYP2C19 Poor Metabolizers among Racial and Ethnic Groups of Eastern Taiwan

東台灣不同族群間在CYP2C19慢代謝者盛行率上存在差異

陳明杰(Ming-Cheh Chen) ； 易志勳(Chih-Hsun Yi) ； 王豊裕(Li-Yu Wang) ； 林憲宏(Hans Hsien-Hong Lin) ； 胡志棠(Chi-Tan Hu)

《臺灣消化醫學雜誌》 30卷4期 (2013/12) Pp. 300-308

https://doi.org/10.6557/GJT.201312_30(4).0002

摘要

Background: CYP2C19 is an enzyme for drug metabolism, and its genetic polymorphisms produce interpersonal variations in drug responses. The two major loss-of-function alleles for poor metabolizers (PMs) for Asian populations were CYP2C19*2 and CYP2C19*3. This study was conducted to assess whether the prevalence of CYP2C19 PM genotypes differs between Han Chinese and Taiwan Aborigines in Eastern Taiwan.Material and Methods: A total of 955 students were selected from six senior high schools in Hualien County, and 938 (98.2%) of them were genotyped for CYP2C19*2 and CYP2C19*3 by direct sequencing method. Individuals with homozygous CYP2C19*2, homozygous CYP2C19*3 or heterozygous CYP2C19*2/*3 were predicted to have the PM phenotype.Results: The prevalence of CYP2C19*2 and CYP2C19*3 in Taiwan Aborigines were higher than those in Han Chinese (40.1% and 9.1% vs. 30.6% and 5.5%, both p ＜ 0.01). The predicted CYP2C19 PM phenotype in Taiwan Aborigines was also higher (23.3% vs. 13.0%, p ＜ 0.01).Conclusion: We showed there are major differences in the prevalences of CYP2C19 PMs among different ethnic groups in Eastern Taiwan.

關鍵字

CYP2C19多態性 ； 慢代謝者基因型 ； 東台灣 ； 族群 ； 藥理基因學差異

並列摘要

Background: CYP2C19 is an enzyme for drug metabolism, and its genetic polymorphisms produce interpersonal variations in drug responses. The two major loss-of-function alleles for poor metabolizers (PMs) for Asian populations were CYP2C19*2 and CYP2C19*3. This study was conducted to assess whether the prevalence of CYP2C19 PM genotypes differs between Han Chinese and Taiwan Aborigines in Eastern Taiwan.Material and Methods: A total of 955 students were selected from six senior high schools in Hualien County, and 938 (98.2%) of them were genotyped for CYP2C19*2 and CYP2C19*3 by direct sequencing method. Individuals with homozygous CYP2C19*2, homozygous CYP2C19*3 or heterozygous CYP2C19*2/*3 were predicted to have the PM phenotype.Results: The prevalence of CYP2C19*2 and CYP2C19*3 in Taiwan Aborigines were higher than those in Han Chinese (40.1% and 9.1% vs. 30.6% and 5.5%, both p ＜ 0.01). The predicted CYP2C19 PM phenotype in Taiwan Aborigines was also higher (23.3% vs. 13.0%, p ＜ 0.01).Conclusion: We showed there are major differences in the prevalences of CYP2C19 PMs among different ethnic groups in Eastern Taiwan.

並列關鍵字

CYP2C19 Polymorphism ； poor metabolizer genotypes ； Eastern Taiwan ； ethnic groups ； pharmacogenetic difference