- 期刊
Antitubercular Resorcinols and Cytotoxic Alkyl Benzoquinones from Ardisia kusukuensis
並列摘要
Bioassay-guided fractionation of the whole plant of Ardisia kusukuensis led to the isolation of six new resorcinols: kusukuenols A, (1), A2 (2), kusukuenols B, (3), B2 (4), and kusuennols C, (5), C2 (6), together with 21 known compounds including six alkenyl resorcinols: 5-(8'Z-heptadecenyl) resorcinol (7), 5-(8' Z-pentadecenyl)resorcinol (8), 2-methyl-5-(8' Z-heptadecenyl)resorcinol (9), 2-methyl-5-(8'Z-pentadecenyl)resorcinol (10), oncostemonol D (11), dehydrobisgravillol (12); three alkyl resorcinols: bisgravillol (13), 1-(3, 5-dihydroxyphenyl) nonan-1-one (14) and 1-(3, 5-dihydroxyphenyl) heptan-1-one (15); two benzoquinones: ardisianone (16) and cornudentanone (17); two benzenoids: 4-h ydroxybenzoic acid (18) and hydroquinone (19); two chlorophylls: pheophytin-a (20) and 132-hydroxy-(13^2-S)-pheophytin-a (21); six s teroids: α-s pinasterol (22), a mixture of β-sitosterol (23) and stigmasterol (24), a mixture of 6β-hydroxystigmasta-4-en-3-one (25), 6β-hydroxystigmasta-4, 22-dien-3-one (26), and 6β-hydroxycampest-4-en-3-one (27). The structures of these compounds were determined by spectroscopic analysis and chemical derivation. Among the isolates, compounds 2, 7, 8, 10, 15, and 19 exhibited potent antitubercular activities (MIC values ≤29.0μg/mL) against Mycobacterium tuberculosis H37Rv in vitro. Two alkyl benzoquinones, 16 and 17 were the cytotoxic constituents.