台灣成年人非酒精性脂肪肝相關因子之分析

Associated Factors of Non-alcoholic Fatty Liver among Adults in Taiwan

楊逸菊(Yi-Chu Yang) ； 謝蕙宜(Hui-I Hsieh) ； 陳振寬(Tzen-Kwan Chen) ； 林敏雄(Min-Shung Lin)

《中華民國家庭醫學雜誌》 10卷2期 (2000/06) Pp. 59-66

https://doi.org/10.7023/CJFM.200006.0059

摘要

脂肪肝為成年人健康檢查中常見的腹部超音波異常。為了檢測脂肪肝與其他代謝因子的相關性，我們回溯性地以台北市國泰綜合醫院，1999年9月10月全身健康檢查中，無飲酒習慣且年紀介於25-64歲間，共429人為研究對象，其中148人(34.5%)經腹部超音波診斷患有脂肪肝。分析變項包括性別、年紀、身體質量指數、飯前血糖指數、糖化血紅素、肝功能指數、膽固醇指數及三酸甘油脂指數。單變項分析結果顯示，成年人非酒精性脂肪肝的罹病率，男性高於女性，中年高於壯年，而相關的代謝因子包括身體質量指數、飯前血糖指數、糖化血紅素、肝功能指數、膽固醇指數，及三酸甘油脂指數。以多變項邏輯斯締迴歸模式作進一步分析，發現身體質量指數、三酸甘油脂指數、膽固醇指數，為非酒精性脂肪肝具有意義的相關因子。因此。適當地控制體重及高脂血症，可能有助於非酒精性脂肪肝的防治。

並列摘要

Fatty liver is an abnormal finding frequently seen in abdominal ultrasound scans of middle-aged people. In order to investigate the factors associated with non-alcoholic fatty liver in Taiwan, we conducted a retrospective tracking of physical examinations performed at Cathay General Hospital Between September and October of 1999 in individuals between 25 and 64 years of age with no history of alcohol abuse. A total of 429 patients were examined, in which 148 (34.5%) demonstrated a fatty liver using abdominal ultrasound. Factors considered included gender, body mass index (BMI), age, fasting glucose, HbA1C, liver function indices (GOT, GPT, γ-GT), and serum lipid profile. The results of the analysis revealed that in terms of prevalence of non-alcoholic fatty liver in middle-aged individuals, males exhibited a higher incidence than females, with associated factors such as BMI, fasting glucose, liver function indices, triglyceride index and total cholesterol. Multiple logistic regression was used in further analysis, showing that increased BMI, total cholesterol and triglyceride were significant associated factors for the presence of a fatty liver. Our data, consistent with previous reports, indicate the importance of the maintenance of ideal body weight and normal serum lipid profile on the control of non-alcoholic fatty liver.

並列關鍵字

prevalence ； obesity ； hyperlipidemia ； fatty liver